J
Jaroslaw Grabowski
Researcher at Max Planck Society
Publications - 4
Citations - 320
Jaroslaw Grabowski is an academic researcher from Max Planck Society. The author has contributed to research in topics: Total synthesis & Prodigiosin. The author has an hindex of 3, co-authored 4 publications receiving 314 citations.
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Total Synthesis and Structural Refinement of the Cyclic Tripyrrole Pigment Nonylprodigiosin
TL;DR: X-ray data of product 18 suggest that the tautomeric form B properly describes the electron distribution within the heteroaromatic segment of this alkaloid, in which the central ring constitutes the azafulvene unit of the pyrrolylpyrromethene chromophore.
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Ring-closing alkyne metathesis. Application to the total synthesis of sophorolipid lactone.
TL;DR: The first total synthesis of a major component of the microbial biosurfactant sophorolipid has been achieved using a ring-closing metathesis reaction of diyne 21 catalyzed by Mo[N(t-Bu)(Ar)](3) (5; Ar = 3,5-dimethylphenyl) activated in situ by CH(2)Cl(2), followed by Lindlar reduction of the resulting cycloalkyne 22.
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Synthesis and Biological Evaluation of Nonylprodigiosin and Macrocyclic Prodigiosin Analogues
TL;DR: The immunosuppressive activity of prodigiosins toward T‐cell proliferation seems to be mediated through cellular targets distinct from vacuolar acidification, and the prodigioin analogues might be powerful tools to dissect these biological responses.