J
Jarushka Naidoo
Researcher at Johns Hopkins University
Publications - 181
Citations - 13280
Jarushka Naidoo is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Lung cancer & Medicine. The author has an hindex of 38, co-authored 139 publications receiving 7798 citations. Previous affiliations of Jarushka Naidoo include Connolly Hospital Blanchardstown & Kettering University.
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Journal ArticleDOI
Neoadjuvant PD-1 Blockade in Resectable Lung Cancer
Patrick M. Forde,Jamie E. Chaft,Kellie N. Smith,Valsamo Anagnostou,Tricia R. Cottrell,Matthew D. Hellmann,Marianna Zahurak,Stephen C. Yang,David R. Jones,Stephen R. Broderick,Richard J. Battafarano,Moises J. Velez,Natasha Rekhtman,Zachary T. Olah,Jarushka Naidoo,Kristen A. Marrone,Franco Verde,Haidan Guo,Jiajia Zhang,Justina X. Caushi,Hok Yee Chan,John-William Sidhom,Robert B. Scharpf,James R. White,Edward Gabrielson,Hao Wang,Gary L. Rosner,Valerie W. Rusch,Jedd D. Wolchok,Taha Merghoub,Janis M. Taube,Victor E. Velculescu,Suzanne L. Topalian,Julie R. Brahmer,Drew M. Pardoll +34 more
TL;DR: Nivolumab was associated with few side effects, did not delay surgery, and induced a major pathological response in 45% of resected tumors, and the tumor mutational burden was predictive of the pathological response to PD‐1 blockade.
Journal ArticleDOI
Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study.
Nicole M. Kuderer,Toni K. Choueiri,Dimpy P. Shah,Yu Shyr,Samuel M. Rubinstein,Donna R. Rivera,Sanjay Shete,Chih-Yuan Hsu,Aakash Desai,Gilberto Lopes,Petros Grivas,Petros Grivas,Corrie A. Painter,Solange Peters,Michael A. Thompson,Ziad Bakouny,Gerald Batist,Tanios Bekaii-Saab,Mehmet Asim Bilen,Nathaniel Bouganim,Mateo Bover Larroya,Daniel Castellano,Salvatore Del Prete,Deborah B. Doroshow,Pamela C Egan,Arielle Elkrief,Dimitrios Farmakiotis,Daniel Blake Flora,Matthew D. Galsky,Michael Glover,Elizabeth A. Griffiths,Anthony P. Gulati,Shilpa Gupta,Navid Hafez,Thorvardur R. Halfdanarson,Jessica Hawley,Emily Hsu,Anup Kasi,Ali Raza Khaki,Ali Raza Khaki,Christopher Lemmon,Colleen Lewis,Barbara Logan,Tyler Masters,Rana R. McKay,Ruben A. Mesa,Alicia K. Morgans,Mary F. Mulcahy,Orestis A. Panagiotou,Prakash Peddi,Nathan A. Pennell,Kerry L. Reynolds,Lane R. Rosen,Rachel P. Rosovsky,Mary Salazar,Andrew Schmidt,Sumit A. Shah,Justin Shaya,John A. Steinharter,Keith Stockerl-Goldstein,Suki Subbiah,Donald C. Vinh,Firas Wehbe,Lisa Weissmann,Julie Tsu Yu Wu,Elizabeth Marie Wulff-Burchfield,Zhuoer Xie,Albert C. Yeh,Albert C. Yeh,Peter Paul Yu,Alice Zhou,Leyre Zubiri,Sanjay Mishra,Gary H. Lyman,Gary H. Lyman,Brian I. Rini,Jeremy L. Warner,Maheen Z. Abidi,Jared D. Acoba,Neeraj Agarwal,Syed A. Ahmad,Archana Ajmera,Jessica K. Altman,Anne H. Angevine,Nilo Azad,Michael H. Bar,Aditya Bardia,Jill S. Barnholtz-Sloan,Briana Barrow,Babar Bashir,Rimma Belenkaya,Stephanie Berg,Eric H. Bernicker,Christine Bestvina,Rohit Bishnoi,Genevieve M. Boland,Mark Bonnen,Gabrielle Bouchard,Daniel W. Bowles,Fiona Busser,Angelo Cabal,Paolo Caimi,Theresa M. Carducci,Carla Casulo,James L. Chen,Jessica M. Clement,David D. Chism,Erin Cook,Catherine Curran,Ahmad Daher,Mark E. Dailey,Saurabh Dahiya,John F. Deeken,George D. Demetri,Sandy DiLullo,Narjust Duma,Rawad Elias,Bryan A. Faller,Leslie A. Fecher,Lawrence E. Feldman,Christopher R. Friese,Paul Fu,Julie Fu,Andy Futreal,Justin F. Gainor,Jorge A. Garcia,David Gill,Erin A. Gillaspie,Antonio Giordano,Grace Glace,Axel Grothey,Shuchi Gulati,Michael J. Gurley,Balazs Halmos,Roy S. Herbst,Dawn L. Hershman,Kent Hoskins,Rohit Jain,Salma K. Jabbour,Alokkumar Jha,Douglas B. Johnson,Monika Joshi,Kaitlin M. Kelleher,Jordan Kharofa,Hina Khan,Jeanna Knoble,Vadim S. Koshkin,Amit Kulkarni,Philip E. Lammers,John C. Leighton,Mark A. Lewis,X. Li,Ang Li,K. M.Steve Lo,Arturo Loaiza-Bonilla,Patricia LoRusso,Clarke A. Low,Maryam B. Lustberg,Daruka Mahadevan,Abdul Hai Mansoor,Michelle Marcum,Merry Jennifer Markham,Catherine Handy Marshall,Sandeep H. Mashru,Sara Matar,Christopher McNair,Shannon K. McWeeney,Janice M. Mehnert,Alvaro G. Menendez,Harry Menon,Marcus Messmer,Ryan Monahan,Sarah Mushtaq,Gayathri Nagaraj,Sarah Nagle,Jarushka Naidoo,John M. Nakayama,Vikram M. Narayan,Heather H. Nelson,Eneida R. Nemecek,Ryan Nguyen,Pier Vitale Nuzzo,Paul E. Oberstein,Adam J. Olszewski,Susie Owenby,Mary M. Pasquinelli,John Philip,Sabitha Prabhakaran,Matthew Puc,Amelie G. Ramirez,Joerg Rathmann,Sanjay G. Revankar,Young Soo Rho,Terence Duane Rhodes,Robert L. Rice,Gregory J. Riely,Jonathan Riess,Cameron Rink,Elizabeth Robilotti,Lori J. Rosenstein,Bertrand Routy,Marc A. Rovito,M. Wasif Saif,Amit Sanyal,Lidia Schapira,Candice Schwartz,Oscar K. Serrano,Mansi R. Shah,Chintan Shah,Grace Shaw,Ardaman Shergill,Geoffrey Shouse,Heloisa P. Soares,Carmen C. Solorzano,Pramod K. Srivastava,Karen Stauffer,Daniel G. Stover,Jamie Stratton,Catherine Stratton,Vivek Subbiah,Rulla M. Tamimi,Nizar M. Tannir,Umit Topaloglu,Eli Van Allen,Susan Van Loon,Karen Vega-Luna,Neeta K. Venepalli,Amit Verma,Praveen Vikas,Sarah Wall,Paul L. Weinstein,Matthias Weiss,Trisha Wise-Draper,William A. Wood,Wenxin Xu,Susan Yackzan,Rosemary Zacks,Tian Zhang,Andrea J. Zimmer,Jack West +239 more
TL;DR: The outcomes of a cohort of patients with cancer and COVID-19 are characterised and potential prognostic factors for mortality and severe illness are identified and race and ethnicity, obesity status, cancer type, type of anticancer therapy, and recent surgery were not associated with mortality.
Journal ArticleDOI
Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies
Jarushka Naidoo,David B. Page,Bob T. Li,L. C. Connell,Katja Schindler,Mario E. Lacouture,Mario E. Lacouture,Michael A. Postow,Michael A. Postow,Jedd D. Wolchok,Jedd D. Wolchok +10 more
TL;DR: Clinical studies investigating single-agent anti-PD-1/PD-L1 therapy and trials of combination approaches with other standard anticancer therapies, in multiple tumor types are reviewed and the key adverse events reported in these studies are summarized.
Journal ArticleDOI
Pneumonitis in Patients Treated With Anti–Programmed Death-1/Programmed Death Ligand 1 Therapy
Jarushka Naidoo,Xuan Wang,Xuan Wang,Xuan Wang,Kaitlin M. Woo,Kaitlin M. Woo,Tunc Iyriboz,Tunc Iyriboz,Darragh Halpenny,Jane Cunningham,Jane Cunningham,Jamie E. Chaft,Jamie E. Chaft,Neil H. Segal,Neil H. Segal,Margaret K. Callahan,Margaret K. Callahan,Alexander M. Lesokhin,Alexander M. Lesokhin,Jonathan E. Rosenberg,Jonathan E. Rosenberg,Martin H. Voss,Martin H. Voss,Charles M. Rudin,Charles M. Rudin,Hira Rizvi,Hira Rizvi,Xue Hou,Xue Hou,Katherine Rodriguez,Katherine Rodriguez,Melanie Albano,Ruth Ann Gordon,Ruth Ann Gordon,Charles Leduc,Charles Leduc,N. Rekhtman,N. Rekhtman,Bianca Harris,Bianca Harris,Alexander M. Menzies,Alexander M. Menzies,Alexander D. Guminski,Matteo S. Carlino,Matteo S. Carlino,Benjamin Y. Kong,Benjamin Y. Kong,Jedd D. Wolchok,Jedd D. Wolchok,Michael A. Postow,Georgina V. Long,Matthew D. Hellmann,Matthew D. Hellmann +52 more
TL;DR: Pneumonitis associated with anti- PD-1/PD-L1 mAbs is a toxicity of variable onset and clinical, radiologic, and pathologic appearances that is more common when anti-PD-1-L 1 mAbs are combined withAnti-cytotoxic T-cell lymphocyte-4 mAb.
Journal ArticleDOI
Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer
Valsamo Anagnostou,Kellie N. Smith,Patrick M. Forde,Noushin Niknafs,Rohit Bhattacharya,James R. White,Theresa Zhang,Vilmos Adleff,Jillian Phallen,Neha Wali,Carolyn Hruban,Violeta Beleva Guthrie,Kristen Rodgers,Jarushka Naidoo,Hyunseok Kang,William H. Sharfman,Christos S. Georgiades,Franco Verde,Peter B. Illei,Qing Kay Li,Edward Gabrielson,Malcolm V. Brock,Cynthia A. Zahnow,Stephen B. Baylin,Robert B. Scharpf,Julie R. Brahmer,Rachel Karchin,Drew M. Pardoll,Victor E. Velculescu +28 more
TL;DR: This work demonstrates for the first time that acquired resistance to immune checkpoint blockade can arise in association with the evolving landscape of mutations, some of which encode tumor neoantigens recognizable by T cells.