Jaruwan Tritipsombut

TL;DR: The results indicate that thalassemia and hemoglobinopathies are a significant health burden in the region and that a prevention and control program for severe thalassesmia diseases should be established in Laos.

TL;DR: A simple molecular technique based on a single-tube multiplex gap-polymerase chain reaction (PCR) has been developed in this study that provides a fast, simple and cost effective diagnostic test for deletion types of β-thal that can be applied in every molecular diagnostic laboratory having standard PCR equipment.

TL;DR: Effective primary screening with 100% accuracy for alpha-thalassemia 1 and hemoglobin E in newborns in the region could be carried out using means corpuscular volume less than 95 fL, mean corpuscular hemoglobin less than 30 pg, or hemoglobin Bart greater than 8.0% and Hemoglobin E greater than 0.5%, respectively.

TL;DR: The findings indicate that proficiency testing and regular training programs are needed to decrease false negative results and to monitor regularly the screening performance of the community hospitals.

TL;DR: Comparison of the difference-values of Hb Bart’s and Hb E levels obtained from the 2 different automated-HPLC-analyzers revealed a median (95% CI) of -0.2 (-0.3, -1.1), indicating that these values were significantly different (P