Jas.B. Macalpine

Bio: Jas.B. Macalpine is an academic researcher from University of Salford. The author has contributed to research in topics: Renal pelvis & Lumen (anatomy). The author has an hindex of 6, co-authored 7 publications receiving 112 citations.

Collecting duct carcinoma of the kidney.

Abstract: Six cases of renal epithelial neoplasms, which show atypical histological features previously described in cases of collecting duct carcinomas, are presented. The tumours were of a tubulo-papillary architecture, arose in the renal medulla and showed prominent infiltrating tubules with an associated desmoplastic reaction. Atypical hyperplastic changes were present in the medullary collecting ducts in five cases.

Changing picture of facial fractures in northern Nigeria

Abstract: This was a prospective study that aimed to find out the current pattern of facial fractures in northern Nigeria and to see if changes in the socioeconomic conditions in Nigeria during the past 20-30 years have affected the aetiology, sex and age distribution of the patients, and type of facial fractures. The setting was the maxillofacial unit of the University of Maiduguri Teaching Hospital, which is the only referral centre for facial trauma in north-eastern Nigeria, serving a population of about 30 million people. All 306 patients were treated for facial fracture between January 1996 and December 1999. Most of the patients (126/306, 41%) were in the age range 21-30 years and the male to female ratio was 2.19:1. The main causes of the fractures were assault (n = 147, 48%) followed by road traffic accidents (n = 111, 36%). Other aetiological factors such as falls, and sports or industrial accidents accounted for the remaining cases. Of the assault-related injuries 102 (33%) were the result of armed robbery and 45 (15%) the result of fights, mainly on the farms. The mandible was the most common site of fractures (n = 273, 89%) and most of the mandibular fractures were in the body of the mandible. Only 44/306 patients (14%) reported to the hospital within the first 24 hours after injury. Changing socioeconomic conditions are associated with an increase in assault-related facial fractures, but the predominantly affected age group, sex and site of fracture remain relatively constant.

Uroepithelial tumors of the renal pelvis associated with abuse of phenacetin-containing analgesics.

Abstract: This is a review of 62 patients with abuse of phenacetin-containing drugs and uroepithelial tumors of the renal pelvis. Most of the patients had a pre-existing nephropathy with papillary necrosis as a prominent feature. Fifty-six per cent of the patients have died, most of them from the tumor disease, but many were uremic at the time of death. Thus, the co-existing nephropathy contributed to the poor prognosis. The risk of overlooking an early tumor diagnosis is emphasized. Patients with a known nephropathy with papillary necrosis should be followed continuously, and even the finding of a discrete microscopic hematuria should prompt reinvestigation with radiologic examination of the kidneys. The diagnosis of a uroepithelial tumor of the renal pelvis should always lead to an analysis of the analgesic consumption, besides looking for occupational factors. On the basis of present knowledge of urinary tract carcinogens and phenacetin metabolites it is assumed that phenacetin is the crucial factor for the development of uroepithelial tumors in this study.