J
Jaskunas
Researcher at Eli Lilly and Company
Publications - 2
Citations - 567
Jaskunas is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Structure–activity relationship & Trovirdine. The author has an hindex of 2, co-authored 2 publications receiving 543 citations.
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Journal ArticleDOI
Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs.
F W Bell,Cantrell As,Marita Högberg,Jaskunas,Johansson Nils Gunnar,C. L. Jordan,Kinnick,Peter Thomas Lind,J. M. Jun. Morin,Rolf Noreen +9 more
TL;DR: A novel series of potent specific HIV-1 inhibitory compounds is described and the identification of N-(2-pyridyl)-N'-(5-bromo-2- pyridol)-thiourea (62; LY300046.HCl) as a candidate for clinical evaluation is identified.
Journal ArticleDOI
Phenethylthiazolylthiourea (PETT) Compounds as a New Class of HIV-1 Reverse Transcriptase Inhibitors. 2. Synthesis and Further Structure−Activity Relationship Studies of PETT Analogs
Cantrell As,P. Engelhardt,Marita Högberg,Jaskunas,N. G. Johansson,C. L. Jordan,J. Kangasmetsa,Kinnick,Peter Thomas Lind,J. M. Jun. Morin,Mark A. Muesing,R. Noreen,B. Oberg,Pranc P,Sahlberg C,Robert J. Ternansky,Robert Theodore Vasileff,L. Vrang,West Sj,H. Zhang +19 more
TL;DR: Trovirdine is identified as a highly potent anti-HIV-1 agent and replacement of the two aromatic moieties of the PETT compounds by various substituted or unsubstituted heteroaromatic rings was investigated.