J
Jason C. O'Connor
Researcher at University of Texas Health Science Center at San Antonio
Publications - 70
Citations - 11934
Jason C. O'Connor is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Kynurenine & Kynurenine pathway. The author has an hindex of 37, co-authored 66 publications receiving 10243 citations. Previous affiliations of Jason C. O'Connor include University of Texas System & University of Illinois at Urbana–Champaign.
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From inflammation to sickness and depression: when the immune system subjugates the brain
TL;DR: In response to a peripheral infection, innate immune cells produce pro-inflammatory cytokines that act on the brain to cause sickness behaviour, which can lead to an exacerbation of sickness and the development of symptoms of depression in vulnerable individuals.
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Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice
Jason C. O'Connor,Marcus A. Lawson,Caroline André,Maïté M. Moreau,Jacques Lestage,Nathalie Castanon,Keith W. Kelley,Keith W. Kelley,Robert Dantzer +8 more
TL;DR: Results implicate IDO as a critical molecular mediator of inflammation-induced depressive-like behavior, probably through the catabolism of tryptophan along the kynurenine pathway.
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Inflammation-associated depression: From serotonin to kynurenine
TL;DR: Although the relative importance of peripherally versus centrally produced kynurenine and the cellular source of production of this compound remain to be determined, these findings provide new targets for the treatment of inflammation-associated depression that could be extended to other psychiatric conditions mediated by activation of neuroimmune mechanisms.
Journal ArticleDOI
Interferon-γ and Tumor Necrosis Factor-α Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guérin
Jason C. O'Connor,Caroline André,Yun-Xia Wang,Marcus A. Lawson,Sandra S. Szegedi,Jacques Lestage,Nathalie Castanon,Keith W. Kelley,Robert Dantzer,Robert Dantzer +9 more
TL;DR: It is demonstrated that IFNγ, with TNFα, is necessary for induction of IDO and depressive-like behavior in mice after BCG infection and synergized to induce IDO in primary microglia.
Journal ArticleDOI
Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior
François Frenois,Maïté M. Moreau,Jason C. O'Connor,Marc A. Lawson,Charlotte Micon,Jacques Lestage,Keith W. Kelley,Robert Dantzer,Nathalie Castanon +8 more
TL;DR: The results provide the first evidence in favor of a functional dissociation between the brain structures that underlie cytokine-induced sickness behavior and cytokin-induced depressive-like behavior, and provide important cues about the neuroanatomical brain circuits through which cytokines could have an impact on affect.