J
Javed Khan
Researcher at National Institutes of Health
Publications - 176
Citations - 15964
Javed Khan is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene expression profiling & Neuroblastoma. The author has an hindex of 55, co-authored 165 publications receiving 14062 citations. Previous affiliations of Javed Khan include Aga Khan University & Advanced Technology Center.
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Journal ArticleDOI
Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks
Javed Khan,Jun S. Wei,Markus Ringnér,Markus Ringnér,Lao H. Saal,Marc Ladanyi,Frank Westermann,Frank Berthold,Manfred Schwab,Cristina R. Antonescu,Carsten Peterson,Paul S. Meltzer +11 more
TL;DR: The ability of the trained ANN models to recognize SRBCTs is demonstrated, and the potential applications of these methods for tumor diagnosis and the identification of candidate targets for therapy are demonstrated.
Journal ArticleDOI
The genetic landscape of high-risk neuroblastoma
Trevor J. Pugh,Olena Morozova,Edward F. Attiyeh,Edward F. Attiyeh,Shahab Asgharzadeh,Shahab Asgharzadeh,Jun S. Wei,Daniel Auclair,Scott L. Carter,Kristian Cibulskis,Megan Hanna,Megan Hanna,Adam Kiezun,Jaegil Kim,Michael S. Lawrence,Lee Lichenstein,Aaron McKenna,Chandra Sekhar Pedamallu,Chandra Sekhar Pedamallu,Alex H. Ramos,Alex H. Ramos,Erica Shefler,Andrey Sivachenko,Carrie Sougnez,Chip Stewart,Adrian Ally,Inanc Birol,Readman Chiu,Richard Corbett,Martin Hirst,Shaun D. Jackman,Baljit Kamoh,Alireza Hadj Khodabakshi,Martin Krzywinski,Allan Lo,Richard A. Moore,Karen Mungall,Jenny Q. Qian,Angela Tam,Nina Thiessen,Yongjun Zhao,Kristina A. Cole,Kristina A. Cole,Maura Diamond,Maura Diamond,Sharon J. Diskin,Sharon J. Diskin,Yael P. Mosse,Yael P. Mosse,Andrew Wood,Andrew Wood,Lingyun Ji,Lingyun Ji,Richard Sposto,Richard Sposto,Thomas C. Badgett,Wendy B. London,Yvonne Moyer,Yvonne Moyer,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Malcolm A. Smith,Jaime M. Guidry Auvil,Daniela S. Gerhard,Michael D. Hogarty,Michael D. Hogarty,Steven J.M. Jones,Eric S. Lander,Stacey Gabriel,Gad Getz,Robert C. Seeger,Robert C. Seeger,Javed Khan,Marco A. Marra,Matthew Meyerson,Matthew Meyerson,John M. Maris +76 more
TL;DR: The authors reported a low median exonic mutation frequency of 0.60 per Mb (0.48 nonsilent) and notably few recurrently mutated genes in high-risk neuroblastoma.
Journal ArticleDOI
Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome
Amy P. Hsu,Elizabeth P. Sampaio,Javed Khan,Katherine R. Calvo,Jacob E. Lemieux,Smita Y. Patel,David M. Frucht,Donald C. Vinh,Roger D. Auth,Alexandra F. Freeman,Kenneth N. Olivier,Gulbu Uzel,Christa S. Zerbe,Christine Spalding,Stefania Pittaluga,Mark Raffeld,Douglas B. Kuhns,Li Ding,Michelle L. Paulson,Michelle L. Paulson,Beatriz E. Marciano,Juan Gea-Banacloche,Jordan S. Orange,Jennifer Cuellar-Rodriguez,Dennis D. Hickstein,Steven M. Holland +25 more
TL;DR: GATA2 joins RUNX1 and CEBPA not only as a familial leukemia gene but also as a cause of a complex congenital immunodeficiency that evolves over decades and combines predisposition to infection and myeloid malignancy.
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Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors
Jack F. Shern,Li Chen,Juliann Chmielecki,Jun S. Wei,Rajesh Patidar,Mara Rosenberg,Lauren Ambrogio,Daniel Auclair,Jianjun Wang,Young K. Song,Catherine Tolman,Laura Hurd,Hongling Liao,Shile Zhang,Dominik Bogen,Andrew S. Brohl,Sivasish Sindiri,Daniel Catchpoole,Thomas C. Badgett,Gad Getz,Jaume Mora,James R. Anderson,Stephen X. Skapek,Frederic G. Barr,Matthew Meyerson,Matthew Meyerson,Douglas S. Hawkins,Javed Khan +27 more
TL;DR: This is the most comprehensive genomic analysis of rhabdomyosarcoma to date, finding multiple genes were recurrently altered, including NRAS, KRAS, HRAS, FGFR4, PIK3CA, CTNNB1, FBXW7, and BCOR.
Journal ArticleDOI
Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators
TL;DR: In vivo functional studies revealed that the actin filament–plasma membrane linker ezrin and the homeodomain-containing transcription factor Six-1 had essential roles in determining the metastatic fate of RMS cells.