J
Javier Escabi
Researcher at Harvard University
Publications - 3
Citations - 112
Javier Escabi is an academic researcher from Harvard University. The author has contributed to research in topics: Progenitor cell & Population. The author has an hindex of 3, co-authored 3 publications receiving 37 citations.
Papers
More filters
Journal ArticleDOI
Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms
Debra Van Egeren,Debra Van Egeren,Javier Escabi,Maximilian Nguyen,Shichen Liu,Christopher R. Reilly,Sachin Patel,Baransel Kamaz,Maria Kalyva,Daniel J. DeAngelo,Ilene Galinsky,Martha Wadleigh,Eric S. Winer,Marlise R. Luskin,Richard Stone,Jacqueline S. Garcia,Gabriela S. Hobbs,Fernando D. Camargo,Fernando D. Camargo,Franziska Michor,Ann Mullally,Ann Mullally,Ann Mullally,Isidro Cortes-Ciriano,Sahand Hormoz,Sahand Hormoz +25 more
TL;DR: This article quantified the effect of the JAK2-V617F mutation on the self-renewal and differentiation dynamics of HSCs in treatment-naive individuals with myeloproliferative neoplasms and reconstructed lineage histories of individual hematopoietic stem cells using somatic mutation patterns.
Journal ArticleDOI
Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Hematopoietic Stem Cells in JAK2-Mutant Myeloproliferative Neoplasms
Debra Van Egeren,Javier Escabi,Maximilian Nguyen,Shichen Liu,Christopher R. Reilly,Sachin Patel,Baransel Kamaz,Maria Kalyva,Daniel J. DeAngelo,Ilene Galinsky,Martha Wadleigh,Eric S. Winer,Marlise R. Luskin,Richard Stone,Jacqueline S. Garcia,Gabriela S. Hobbs,Fernando D. Camargo,Franziska Michor,Ann Mullally,Ann Mullally,Isidro Cortes-Ciriano,Sahand Hormoz +21 more
TL;DR: The studies suggest that the JAK2V617F mutation alone is sufficient to initiate and engender MPN, which has important therapeutic implications, and indicates that theJAK2-mutant clone may manifest as clonal hematopoiesis of indeterminate potential (CHIP) for a decade or more before presenting as an overt MPN.
Posted ContentDOI
Reconstructing the lineage histories and differentiation trajectories of individual cancer cells in JAK2-mutant myeloproliferative neoplasms
Debra Van Egeren,Debra Van Egeren,Javier Escabi,Maximilian Nguyen,Shichen Liu,Christopher R. Reilly,Sachin Patel,Baransel Kamaz,Maria Kalyva,Daniel J. DeAngelo,Ilene Galinsky,Martha Wadleigh,Eric S. Winer,Marlise R. Luskin,Richard Stone,Jacqueline S. Garcia,Gabriela S. Hobbs,Fernando D. Camargo,Fernando D. Camargo,Franziska Michor,Ann Mullally,Ann Mullally,Ann Mullally,Isidro Cortes-Ciriano,Sahand Hormoz,Sahand Hormoz +25 more
TL;DR: This work reconstructed the lineage history of individual HSCs obtained from MPN patients using the patterns of spontaneous somatic mutations accrued in their genomes over time and found that the JAK2-V617F mutation occurred in a single HSC several decades before MPN diagnosis.