Javier Martín Casielles

Bio: Javier Martín Casielles is an academic researcher from University of Chile. The author has contributed to research in topics: Amalgam (dentistry) & Arginine deiminase. The author has an hindex of 3, co-authored 10 publications receiving 30 citations.

Revista Clínica de Periodoncia, Implantología y Rehabilitación Oral

Abstract: Radicular cyst associated with a geminated tooth: Endodontal-surgical treatment Abstract The surgical-endodontic treatment of teeth with an inflammatory radicular cyst is a clinical challenge due to its great complexity. Even more so, if they are in teeth with develop- ment anomalies such as gemination. The case below shows the repair of an apical lesion by a necro-pulpectomy of the geminated tooth and the enucleation of the adjacent cyst. © 2015 Sociedad de Periodoncia de Chile, Sociedad de Implantologia Oral de Chile y Socie- dad de Protesis y Rehabilitacion Oral de Chile. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).

Sealing of restorations with marginal defects does not affect their longevity

Abstract: Purpose To evaluate sealed amalgam and resin-based composite restorations after 12 years to determine whether sealing minor defects (micro-repairs) enhanced the longevity of restorations. Methods 34 subjects aged 18-80 were recruited. This sample group underwent 137 restorations, including 51 resin-based composite (RC) and 86 amalgam (AM) restorations. Existing restorations with localized, marginal defects were assigned to one of two groups: (a) the Sealing group (n=48, 27 AM; 21 RC) or (b) the Control group (n=89, 59 AM; 30 RC). The quality of each restoration was scored according to the modified USPHS criteria by two examiners at the beginning of the study and after 1-5, 10, and 12 years. Kaplan Meier survival curves were created and a Cox regression was applied to investigate survival variables. Mantel Cox, Wilcoxon, and Friedman tests were performed for comparisons within groups. Results After 12 years, no statistically significant differences were observed for the variables "restorative material" (P= 0.538) or "sealing yes/no" (P= 0.136) with respect to the longevity of the restorations. All groups behaved similarly with regard to marginal adaptation, secondary caries, and tooth sensitivity (P≥ 0.05). Cumulatively, after a 12-year observation period, sealing minor restoration defects did not affect the longevity of the restorations. Clinical significance Sealing minor marginal defects for resin composites or amalgam restorations did not affect their longevity. This intervention may be considered over-treatment for patients with low-to-medium risks for developing dental caries.

Is there difference of Streptococcus mutans count and adherence on amalgam and resin occlusal restorations? A blind clinical study

Abstract: Aim: To compare the number of colony forming units (CFU) and agar adherence of S. mutans on amalgam (AM) and resin composite (RC) occlusal restorations. Sixty-five healthy patients older than 18 years with high caries risk who had at least one occlusal AM and RC restorations (n=130) were selected. Methods: The restorations were evaluated according to the alpha Ryge criteria (Cohen-Kappa 0.8). For each patient, a biofilm sample was taken using an impression tray technique with previously loaded with solid trypticase yeast extract cysteine sucrose with bacitracin agar placed over the AM restorations and RC restorations in the same patients. The tray was placed inside an oven at 37 °C for 48 h, and the S. mutans count was then performed. Data were analyzed with the test Wilcoxon with a 95% confidence level. Results: RC restorations had statistically significant higher number of CFU of S. mutans than AM restorations (p<0.05). Conclusions: In adult patients with high caries risk, RC occlusal surfaces showed greater agar adherence of S. mutans count than AM restorations.

Actividad y efectos de ureasa y arginina deiminasa en saliva y biopelícula oral humana

Abstract: El objetivo de esta revision es mostrar los hallazgos emergentes de las potenciales propiedades anticariogenicas de biomoleculas del metabolismo oral relacionados con la produccion de amonio. El analisis de la literatura soporta una nueva dimension preventiva en el conocimiento de la enfermedad caries dental al estudiar la evidencia in vitro publicada, en la que el amonio producido desde la urea y la arginina del ambiente oral presentan importantes factores endogenos inhibitorios del desarrollo de lesiones de caries dental. Este hecho apoyaria la hipotesis que la produccion de amonio por urealisis y por el sistema de arginina deiminasa, podrian inhibir potencialmente el desarrollo de la caries dental por la neutralizacion de acidos y la estabilizacion de la microbiota oral, favoreciendo las condiciones para el mantenimiento de la salud oral. Esta revision presenta estudios de la actividad enzimatica oral, que puede constituir un prometedor campo para establecer nuevas lineas de investigacion en cariologia, p rticularmente in vivo e in situ, destinados a establecer la efectividad y aplicacion clinica de estos compuestos en la prevencion de caries dental. ABSTRACT. The purpose of this review is to present the emerging findings on the potential anti-cariogenic properties of the bioactive molecules of oral metabolism related with ammonia production. The literature analysis supports a new preventive dimension in the knowledge of dental caries disease by studying the published evidence provided by in vitro and clinical studies, in which the ammonia produced from urea and arginine in the oral environment represents an important endogenous inhibitory factor in the development of dental caries lesions. This fact would support the hypothesis that ammonia production by urease and the arginine deiminase system could potentially inhibit the development of dental caries by neutralizing acids and stabilizing the oral microbiota, thus enhancing the conditions for oral health maintenance. This review presents studies on the oral enzyme activity which may constitute a promising field in the definition of new lines of research in cariology, particularly in vivo and in situ, amed at establishing the effectiveness and clinical application of these compounds in the prevention of dental caries.

Revisión del estado actual de cementos de silicato de calcio en odontología restauradora

Abstract: RESUMEN. Los cementos de silicato de calcio se han aplicado como materiales dentales desde hace mas de veinte anos; sin embargo, su uso en el area de la odontologia restauradora es mas reciente. Mejores propiedades mecanicas y menores tiempos de endurecimiento le permiten ser indicados para una variedad de aplicaciones en las que este material se utiliza como sustituto dentinario, entre ellas el recubrimiento pulpar directo/indirecto y como base/liner cavitario. A su vez, tambien se podria utilizar como material para restaurar esmalte de manera temporal. El presente articulo busca revisar la evidencia cientifica disponible, enfocandola a sus aplicaciones en odontologia restauradora. La informacion se obtuvo a partir de articulos originales de investigacion cientifica y revisiones de literatura, publicados en revistas disponibles en bases de datos como Medline/Pubmed y Scielo, junto a la informacion tecnica otorgada por los fabricantes de estos cementos. El presente trabajo describe la composicion, el modo de empleo, la reaccion de fraguado y la evidencia cientifica sobre las aplicaciones de los cementos de silicato de calcio en odontologia restauradora. Palabras clave: cementos de silicato, cementos dentales, materiales dentales, recubrimiento de la pulpa dental. Abstract. Calcium silicate cements have been used as dental materials for more than twenty years; however, their use in restorative dentistry is more recent. Better mechanical properties and shorter curing times make them suitable for a variety of applications in which they are used as a substitute of dentin, including direct/indirect pulp capping and as cavity base/liner. These materials may also be used to restore enamel temporarily. This article seeks to review the available scientific evidence with a focus on their applications in restorative dentistry. The information was gathered by reviewing original scientific research articles and literature reviews published in journals available in databases such as Medline/Pubmed and Scielo, along with technical information provided by the manufacturers of these cements. This article describes the composition, instructions for use, and curing reaction of calcium silicate cements, as well as the scientific evidence on their applications in restorative dentistry. Key words: silicate cements, dental cements, dental materials, dental pulp capping.

Oral Health Surveys: Basic Methods

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Fracture reasons in ceramic-fused-to-metal restorations (Review)

Abstract: Versch. in: Journal of Oral Rehabilitation 2003 30; 265–269 Ceramic-fused-to-metal restorations are widely used in dentistry with a high degree of general success. Fracture of the ceramic eneers as a result of oral function or trauma is not an uncommon problem in clinical practice. Although fractures of such restorations do not necessarily mean the failure of the restoration, the renewal process is both costly and time consuming and therefore remains a clinical problem. Fractures in the anterior region pose an aesthetic problem but when they are in the posterior, chewing function could also be affected. The published literature reveals that reasons for failures cover a wide spectrum from iatrogenic factors to laboratory mistakes or because of factors related to the inherent structure of the ceramics or simply to trauma.

Evaluation of alternative intra-oral repair techniques for fractured ceramic-fused-to-metal restorations (Review)

Abstract: Versch. in: Journal of Oral Rehabilitation 2003 30; 194–203 Ceramic fractures are serious and costly problems in dentistry. Moreover, they pose an aesthetic and functional dilemma both for the patient and the dentist. This problem has created demand for the development of practical repair options which do not necessitate the removal and remake of the entire restoration. Published literatureon repair techniques for fractured fixed partial dentures, concentrating on the data obtained both from in vitro and in vivo studies, reveals that the repair techniques based on sandblasting and silanization are the most durable in terms of adhesive and cohesive failures compared with those using different etching agents.

Indicators of oral health in older adults with and without the presence of multimorbidity: a cross-sectional study.

Abstract: Purpose The aim of this study was to determine whether there are differences in the distribution of various indicators of oral health among elderly people with and without multimorbidity (ie, two or more chronic diseases). Subjects and methods A cross-sectional, comparative study was conducted using a sample of Mexican elderly individuals aged ≥60 years. The average age of the cohort was 79.06±9.78 years, and 69.1% were women. The variables indicating oral health were as follows: functional dentition, edentulism, hyposalivation, xerostomia, root caries and periodontitis. The multimorbidity variable was operationally categorized as follows: 0= subjects with no chronic disease or one chronic disease and 1= subjects with two or more chronic diseases. Questionnaires were used to collect information on various variables regarding general health. Likewise, the participants underwent a clinical oral examination. The analysis was performed using Stata 11.0. Results The overall prevalence of multimorbidity was 27.3%. The prevalences of various oral health indicators were as follows: without functional dentition 89.9%; hyposalivation 59.7%; edentulism 38.9% and self-reported xerostomia 25.2%. Dental caries were observed in 95.3% of the subjects, and the prevalence of severe periodontitis was 80%. We found a significant difference only in edentulism; its prevalence was higher among subjects with multimorbidity (55.3% vs 32.7%, P=0.015) than among those without multimorbidity. Conclusion The presence of edentulism in this sample of Mexican older adults was higher in subjects with multimorbidity. Multimorbidity and oral diseases constitute a true challenge in elderly people, because they affect quality of life and are associated with high health care costs.

An aggressive central giant cell granuloma in a pediatric patient: case report and review of literature.

Abstract: Central giant cell granulomas are benign tumours of the mandible, presenting in children and young adults. Divided into non- and aggressive subtypes, the aggressive subtype is relatively rare and can occasionally progress rapidly, resulting in significant morbidity. We present a case of an aggressive central giant cell granuloma (CGCG) in a six year-old female. The lesion originated in the right mandibular ramus and progressed rapidly to involve the condyle. Diagnosis was made using a combination of imaging and pathology. A timely en bloc resection of the hemi-mandible was performed with placement of a reconstructive titanium plate and condylar prosthesis. Our case demonstrates the importance of considering CGCG in the differential diagnosis of rapidly progressive mandibular lesions in the pediatric population. Prompt diagnosis and management can greatly improve long-term outcomes.