J
Jay Y. Westcott
Researcher at Anschutz Medical Campus
Publications - 52
Citations - 6212
Jay Y. Westcott is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Leukotriene & Arachidonic acid. The author has an hindex of 30, co-authored 52 publications receiving 6002 citations.
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Journal ArticleDOI
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.
TL;DR: The results suggest that binding and/or phagocytosis of apoptotic cells induces active antiinflammatory or suppressive properties in human macrophages, likely that resolution of inflammation depends not only on the removal of apoptosis but on active suppression of inflammatory mediator production.
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Elevated levels of leukotriene C4 in bronchoalveolar lavage fluid from atopic asthmatics after endobronchial allergen challenge
TL;DR: Sulfidopeptide leukotrienes (LT) C4, D4, and E4 were measured in bronchoalveolar lavage fluid before and 5 min after endobronchial allergen challenge in four subject groups and the best correlation was found between the levels in BALF for the prostanoids PGD2 and TxB2 (r = 0.88).
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Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension
Mark W. Geraci,Bifeng Gao,David Shepherd,Mark D. Moore,Jay Y. Westcott,Karen A. Fagan,Lori Alger,Rubin M. Tuder,Norbert F. Voelkel +8 more
TL;DR: It is concluded that PGIS plays a major role in modifying the pulmonary vascular response to chronic hypoxia, which has important implications for the pathogenesis and treatment of severe pulmonary hypertension.
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Effect of 5-lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma.
Sally E. Wenzel,John B. Trudeau,David A. Kaminsky,Judith Cohn,Richard J. Martin,Jay Y. Westcott +5 more
TL;DR: The importance of LTs in both the inflammation and the physiology of nocturnal asthma is demonstrated, with decreases in LTB4 levels and improvement in FVE1 being associated with significant reductions in 4 A.M.
Journal ArticleDOI
Persistent wheezing in very young children is associated with lower respiratory inflammation.
Marzena E. Krawiec,Jay Y. Westcott,Hong Wei Chu,Silvana Balzar,John B. Trudeau,Lawrence B. Schwartz,Sally E. Wenzel +6 more
TL;DR: It is confirmed that inflammation is present in the airways of very young WC and may differ from patterns seen in adults with asthma.