J
Jean C. Shih
Researcher at University of Southern California
Publications - 158
Citations - 12585
Jean C. Shih is an academic researcher from University of Southern California. The author has contributed to research in topics: Monoamine oxidase & Monoamine oxidase A. The author has an hindex of 53, co-authored 150 publications receiving 11671 citations. Previous affiliations of Jean C. Shih include University of Kansas & Heidelberg University.
Papers
More filters
Journal ArticleDOI
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Olivier Cases,Isabelle Seif,Joseph Grimsby,Patricia Gaspar,Kevin Chen,Sandrine Pournin,Ulrike Müller,Michel Aguet,Charles Babinet,Jean C. Shih,Edward De Maeyer +10 more
TL;DR: Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.
Journal ArticleDOI
Monoamine oxidase: from genes to behavior.
Jean C. Shih,K. Chen,M. J. Ridd +2 more
TL;DR: MAO A and B knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders and show increased reactivity to stress.
Journal ArticleDOI
cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties.
Bach Alfred,Nancy C. Lan,Deborah L. Johnson,Creed W. Abell,Michael E. Bembenek,Sau-Wah Kwan,Peter H. Seeburg,Jean C. Shih +7 more
TL;DR: Using oligonucleotide probes derived from three sequenced peptide fragments, isolated cDNA clones that encode the A and B forms of monoamine oxidase are isolated and the nucleotide sequences of these cDNAs are determined.
Journal ArticleDOI
Monoamine oxidase inactivation: from pathophysiology to therapeutics.
TL;DR: The intriguing hypothesis that the attenuation of the oxidative stress induced by the inactivation of either MAO isoform may contribute to both antidepressant and antiparkinsonian actions of MAO inhibitors is discussed.
Journal ArticleDOI
A transient placental source of serotonin for the fetal forebrain
Alexandre Bonnin,Nick Goeden,Kevin P. Chen,Melissa L. Wilson,Jennifer King,Jean C. Shih,Randy D. Blakely,Evan S. Deneris,Pat Levitt +8 more
TL;DR: A new, direct role for placental metabolic pathways in modulating fetal brain development is revealed and indicates that maternal–placental–fetal interactions could underlie the pronounced impact of 5-HT on long-lasting mental health outcomes.