J
Jean-Charles Faye
Researcher at French Institute of Health and Medical Research
Publications - 60
Citations - 1446
Jean-Charles Faye is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Estrogen receptor & Binding site. The author has an hindex of 24, co-authored 60 publications receiving 1399 citations. Previous affiliations of Jean-Charles Faye include DuPont & Paul Sabatier University.
Papers
More filters
Journal ArticleDOI
Estrogen synthesis, estrogen metabolism, and functional estrogen receptors in rat arterial smooth muscle cells in culture
Francis Bayard,Simone Clamens,Fabienne Meggetto,Nelly Blaes,Georges Delsol,Jean-Charles Faye +5 more
TL;DR: The aromatase and dehydrogenase activity results, coupled with the estrogen receptor immunological, RNA analysis, and transfection data strongly support the contention that rat aortic smooth muscle cells are estrogen target cells.
Journal ArticleDOI
Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells
Marine Goffinet,Mathieu Thoulouzan,Anne Pradines,Isabelle Lajoie-Mazenc,Carolyn Weinbaum,Jean-Charles Faye,Sophie Séronie-Vivien +6 more
TL;DR: Zoledronic acid is currently the most efficient bisphosphonate in metastatic prostate cancer management, its mechanism of action in prostatic cells remains unclear but it is suggested that its main biological actitivity is directed against protein Geranylgeranylation.
Journal ArticleDOI
Molecular Characterization of the Microsomal Tamoxifen Binding Site
Blandine Kedjouar,Philippe de Medina,Moustapha Oulad-Abdelghani,Bruno Payré,Sandrine Silvente-Poirot,Gilles Favre,Jean-Charles Faye,Marc Poirot +7 more
TL;DR: The modulation of the biosynthesis of cholesterol in tumor cell lines by AEBS ligands is investigated, providing strong evidence that the AEBS is a hetero-oligomeric complex including 3β-hydroxysterol-Δ8-ΓΔ7-isomerase and the 3 β-Hydroxysterl-7-reductase as subunits that are necessary and sufficient for tamoxifen binding in mammary cells.
Journal ArticleDOI
RhoB prenylation is driven by the three carboxyl-terminal amino acids of the protein: Evidenced in vivo by an anti-farnesyl cysteine antibody
Rudi Baron,Emmanuelle Fourcade,Isabelle Lajoie-Mazenc,Cuider Allal,Bettina Couderc,Ronald Barbaras,Gilles Favre,Jean-Charles Faye,Anne Pradines +8 more
TL;DR: It is demonstrated that the three last carboxyl amino acids are the main determinants for RhoB prenylation and described an anti-farnesyl cysteine antibody as a useful tool for understanding the cellular control of protein farnesylation.
Journal ArticleDOI
Tamoxifen Is a Potent Inhibitor of Cholesterol Esterification and Prevents the Formation of Foam Cells
Philippe de Medina,Bruno Payré,José Bernad,Isabelle Bosser,Bernard Pipy,Sandrine Silvente-Poirot,Gilles Favre,Jean-Charles Faye,Marc Poirot +8 more
TL;DR: This work constitutes the first evidence that tamoxifen is an inhibitor of ACAT and foam cell formation at therapeutic doses and that this may account for its atheroprotective action.