Author
Jean-Christophe Leroux
Other affiliations: Delaware Biotechnology Institute, McGill University, Université de Montréal ...read more
Bio: Jean-Christophe Leroux is an academic researcher from ETH Zurich. The author has contributed to research in topics: Micelle & Drug carrier. The author has an hindex of 74, co-authored 307 publications receiving 21898 citations. Previous affiliations of Jean-Christophe Leroux include Delaware Biotechnology Institute & McGill University.
Topics: Micelle, Drug carrier, Liposome, Drug delivery, Lymphatic system
Papers published on a yearly basis
Papers
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TL;DR: The innovations in block copolymer synthesis, polymeric micelle preparation and characterization, as well as the relevance of these developments to the field of biomedical research are proposed.
1,358 citations
TL;DR: This study reports for the first time the use of polymer/polyol salt aqueous solutions as gelling systems, suggesting the discovery of a prototype for a new family of thermosetting gels highly compatible with biological compounds.
1,287 citations
TL;DR: This review examines the chemical nature of polymeric micelles as well as the methods used to characterize them with regard to drug delivery and potential medical applications, especially in cancer chemotherapy, are described and discussed.
1,200 citations
TL;DR: This manuscript focuses on aqueous polymeric solutions that form implants in situ in response to temperature change, generally from ambient to body temperature, and mainly reviews the characterization and use of polysaccharides, N-isopropylacrylamide copolymers, poly(ethylene oxide) (poloxamer) and itsCopolymers.
1,157 citations
TL;DR: A global view of organogels is provided, with special emphasis on the interplay between the gelator's structural characteristics and the ensuing intermolecular interactions, for active agent administration via diverse routes such as transdermal, oral, and parenteral.
654 citations
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TL;DR: Chitin is the second most important natural polymer in the world as mentioned in this paper, and the main sources of chitin are two marine crustaceans, shrimp and crabs, which are used for food, cosmetics, biomedical and pharmaceutical applications.
6,365 citations
TL;DR: Recent advances in the design of nanoscale stimuli-responsive systems that are able to control drug biodistribution in response to specific stimuli, either exogenous (variations in temperature, magnetic field, ultrasound intensity, light or electric pulses) or endogenous (changes in pH, enzyme concentration or redox gradients).
Abstract: Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible. Implementation of such devices requires the use of biocompatible materials that are susceptible to a specific physical incitement or that, in response to a specific stimulus, undergo a protonation, a hydrolytic cleavage or a (supra)molecular conformational change. In this Review, we discuss recent advances in the design of nanoscale stimuli-responsive systems that are able to control drug biodistribution in response to specific stimuli, either exogenous (variations in temperature, magnetic field, ultrasound intensity, light or electric pulses) or endogenous (changes in pH, enzyme concentration or redox gradients).
4,836 citations
TL;DR: Hydrogels are an appealing scaffold material because they are structurally similar to the extracellular matrix of many tissues, can often be processed under relatively mild conditions, and may be delivered in a minimally invasive manner.
4,573 citations
4,511 citations