J
Jean Claude Louis
Researcher at Amgen
Publications - 8
Citations - 6315
Jean Claude Louis is an academic researcher from Amgen. The author has contributed to research in topics: Amyloid precursor protein & Amyloid precursor protein secretase. The author has an hindex of 8, co-authored 8 publications receiving 6035 citations.
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Journal ArticleDOI
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
Robert Vassar,Brian D. Bennett,Safura Babu-Khan,Steve Kahn,Elizabeth A. Mendiaz,Paul Denis,David B. Teplow,Sandra Ross,Patricia Amarante,Richard Loeloff,Yi Luo,Seth Fisher,Janis Fuller,Steven P. Edenson,Jackson Lile,Mark A. Jarosinski,Anja Leona Biere,Eileen Curran,Teresa L. Burgess,Jean Claude Louis,Frank H. Collins,James J. S. Treanor,Gary Rogers,Martin Citron +23 more
TL;DR: Overexpression of a transmembrane aspartic protease, termed BACE (for beta-site APP-cleaving enzyme) increased the amount of beta-secretase cleavage products, and these were cleaved exactly and only at known beta- secretase positions.
Journal ArticleDOI
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.
Yi Luo,Brad Bolon,Steve Kahn,Brian D. Bennett,Safura Babu-Khan,Paul Denis,Wei Fan,Hue Kha,Jianhua Zhang,Yunhua Gong,Laura Martin,Jean Claude Louis,Qiao Yan,William G. Richards,Martin Citron,Robert Vassar +15 more
TL;DR: These results provide validation of BACE1 as the major β-secretase in vivo and suggest that therapeutic inhibition of Bace1 for the treatment of Alzheimer's disease may be free of mechanism-based toxicity.
Journal ArticleDOI
AMG 9810 [(E)-3-(4-t-Butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a Novel Vanilloid Receptor 1 (TRPV1) Antagonist with Antihyperalgesic Properties
Narender R. Gavva,Rami Tamir,Yusheng Qu,Lana Klionsky,Tie J. Zhang,David C. Immke,Judy Wang,Dawn Zhu,Todd W. Vanderah,Frank Porreca,Elizabeth M. Doherty,Mark H. Norman,Kenneth D. Wild,Anthony W. Bannon,Jean Claude Louis,James J. S. Treanor +15 more
TL;DR: AMG 9810 is the first cinnamide TRPV1 antagonist reported to block capsaicin-induced eye wiping behavior and reverse hyperalgesia in an animal model of inflammatory pain.
Journal ArticleDOI
Molecular Determinants of Vanilloid Sensitivity in TRPV1
Narender R. Gavva,Lana Klionsky,Yusheng Qu,Licheng Shi,Rami Tamir,Steven P. Edenson,Tie J. Zhang,Vellarkad N. Viswanadhan,Attila Tóth,Larry V. Pearce,Todd W. Vanderah,Frank Porreca,Peter M. Blumberg,Jack Lile,Yax Sun,Ken Wild,Jean Claude Louis,James J. S. Treanor +17 more
TL;DR: Key residues (Met547 and Thr550) in transmembrane regions 3 and 4 of rat and human TRPV1 that confer vanilloid sensitivity, [3H]RTX binding and competitive antagonist binding to rabbit TRpV1 are identified and it is shown that these residues differentially affect ligand recognition as well as the assays of functional response versus ligand binding.
Journal ArticleDOI
Expression analysis of BACE2 in brain and peripheral tissues.
Brian D. Bennett,Safura Babu-Khan,Richard Loeloff,Jean Claude Louis,Eileen Curran,Martin Citron,Robert Vassar +6 more
TL;DR: BACE and BACE2 are unique among aspartic proteases in that they possess a carboxyl-terminal extension with a predicted transmembrane region and together they define a new family.