J
Jean Gabert
Researcher at French Institute of Health and Medical Research
Publications - 92
Citations - 9274
Jean Gabert is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Minimal residual disease & Myeloid leukemia. The author has an hindex of 32, co-authored 87 publications receiving 8868 citations. Previous affiliations of Jean Gabert include Hoffmann-La Roche.
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Journal ArticleDOI
Standardization and quality control studies of ‘real-time’ quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia – A Europe Against Cancer Program
Jean Gabert,Emmanuel Beillard,V H J van der Velden,Wanli Bi,David Grimwade,Niels Pallisgaard,Gisela Barbany,Giovanni Cazzaniga,Jean Michel Cayuela,Hélène Cavé,Fabrizio Pane,J. L. E. Aerts,D De Micheli,X Thirion,V Pradel,Marcos González,Susanne Viehmann,Maria Malec,Giuseppe Saglio,J. J. M. Van Dongen +19 more
TL;DR: The development of standardized protocols for RQ-PCR analysis of FG transcripts provides a milestone for molecular determination of MRD levels and is likely to prove invaluable to the management of patients entered into multicenter therapeutic trials.
Journal ArticleDOI
Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia.
van Dongen Jj,Elizabeth Macintyre,Jean Gabert,Eric Delabesse,Rossi,Giuseppe Saglio,Enrico Gottardi,Alessandro Rambaldi,Gianpietro Dotti,Frank Griesinger,A Parreira,Paula Gameiro,Diáz Mg,Maria Malec,Anthonie Willem Langerak,San Miguel Jf,Andrea Biondi +16 more
TL;DR: The standardized RT-PCR protocol and primer sets can now be used for molecular classification of acute leukemia at diagnosis and for MRD detection during follow-up to evaluate treatment effectiveness.
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Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results
Timothy P. Hughes,Michael W. Deininger,Andreas Hochhaus,Susan Branford,Jerald P. Radich,Jaspal Kaeda,Michele Baccarani,Jorge E. Cortes,Nicholas C.P. Cross,Brian J. Druker,Jean Gabert,David Grimwade,Rüdiger Hehlmann,Suzanne Kamel-Reid,Jeffrey H. Lipton,Janina A. Longtine,Giovanni Martinelli,Giuseppe Saglio,Simona Soverini,Wendy Stock,John M. Goldman +20 more
TL;DR: Suggestions are made for harmonizing the differing methodologies for measuring BCR-ABL transcripts in patients with CML undergoing treatment and using a conversion factor whereby individual laboratories can express BCR -ABL transcript levels on an internationally agreed scale.
Journal ArticleDOI
Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - a Europe against cancer program
Emmanuel Beillard,Niels Pallisgaard,V H J van der Velden,Wanli Bi,R Dee,E van der Schoot,Eric Delabesse,E Macintyre,Enrico Gottardi,Giuseppe Saglio,F Watzinger,Thomas Lion,J. J. M. Van Dongen,Peter Hokland,Jean Gabert +14 more
TL;DR: The ABL gene is proposed to be used as CG for RQ-PCR-based diagnosis and MRD detection in leukemic patients and these data are not only eligible for quantifying of fusion gene transcripts, but also for the quantification of aberrantly expressed genes.
Journal ArticleDOI
Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principles, approaches, and laboratory aspects.
V H J van der Velden,Andreas Hochhaus,Giovanni Cazzaniga,Tomasz Szczepański,Jean Gabert,J. J. M. Van Dongen +5 more
TL;DR: The interpretation of RQ-PCR MRD data needs standardized criteria and reporting of MRDData needs international uniformity, and several European networks have now been established and common guidelines for data analysis and for reporting ofMRD data are being developed.