J
Jean Hausser
Researcher at Weizmann Institute of Science
Publications - 37
Citations - 8808
Jean Hausser is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: microRNA & Regulation of gene expression. The author has an hindex of 26, co-authored 35 publications receiving 7908 citations. Previous affiliations of Jean Hausser include University of Basel & Swiss Institute of Bioinformatics.
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Journal ArticleDOI
Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP
Markus Hafner,Markus Landthaler,Lukas Burger,Mohsen Khorshid,Jean Hausser,Philipp Berninger,Andrea Rothballer,Manuel Ascano,Anna-Carina Jungkamp,Mathias Munschauer,Alexander Ulrich,Greg S. Wardle,Scott Dewell,Mihaela Zavolan,Thomas Tuschl +14 more
TL;DR: This study developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs and revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions.
Journal ArticleDOI
MicroRNAs 103 and 107 regulate insulin sensitivity
Mirko Trajkovski,Jean Hausser,Jean Hausser,Jiirgen Soutschek,Bal Bhat,Akinc Akin,Mihaela Zavolan,Markus H. Heim,Markus H. Heim,Markus Stoffel +9 more
TL;DR: It is shown that the expression of microRNAs 103 and 107 (miR-103/107) is upregulated in obese mice and caveolin-1, a critical regulator of the insulin receptor, is identified as a direct target gene of miR- 103/107, as a new target for the treatment of type 2 diabetes and obesity.
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miR-375 maintains normal pancreatic α- and β-cell mass
Matthew N. Poy,Jean Hausser,Mirko Trajkovski,Matthias Braun,Stephan C. Collins,Patrik Rorsman,Mihaela Zavolan,Markus Stoffel +7 more
TL;DR: It is shown that microRNA-375 (miR-375), which is highly expressed in pancreatic islets, is required for normal glucose homeostasis and adaptive β-cell expansion in response to increasing insulin demand in insulin resistance.
Journal ArticleDOI
Identification and consequences of miRNA-target interactions--beyond repression of gene expression
Jean Hausser,Mihaela Zavolan +1 more
TL;DR: The recent progress in identifying miRNA targets and the emerging paradigms of how miRNAs shape the dynamics of target gene expression are reviewed.
Journal ArticleDOI
A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins
Shivendra Kishore,Lukasz Jaskiewicz,Lukas Burger,Jean Hausser,Mohsen Khorshid,Mihaela Zavolan +5 more
TL;DR: The results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites.