Jean-Louis Lefebvre

TL;DR: Postoperative concurrent administration of high-dose cisplatin with radiotherapy is more efficacious than radiotherapy alone in patients with locally advanced head and neck cancer and does not cause an undue number of late complications.

TL;DR: Induction chemotherapy with the addition of docetaxel significantly improved progression-free and overall survival in patients with unresectable squamous-cell carcinoma of the head and neck.

TL;DR: Larynx preservation without jeopardizing survival appears feasible in patients with cancer of the hypopharynx in a prospective, randomized phase III study conducted by the EORTC to compare a larynx-preserving treatment with conventional treatment.

TL;DR: Evidence supports the use of larynx-preservation approaches for appropriately selected patients without a compromise in survival; however, no larynic cancer treatment approach offers a survival advantage compared with total laryngectomy and adjuvant therapy with rehabilitation as indicated.

TL;DR: There is no evidence that one treatment was superior to the other or could improve the outcome reported with ICT followed by RT alone, and the protocol that can best compare with RT alone after ICT is still to be determined.