J
Jean Paul Mira
Researcher at Scripps Research Institute
Publications - 1
Citations - 653
Jean Paul Mira is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Transactivation & Cell signaling. The author has an hindex of 1, co-authored 1 publications receiving 627 citations. Previous affiliations of Jean Paul Mira include Cochin University of Science and Technology.
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Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
Laurence Arbibe,Jean Paul Mira,Jean Paul Mira,Nicole Teusch,Lois Kline,Mausumee Guha,Nigel Mackman,Paul J. Godowski,Richard J. Ulevitch,Ulla G. Knaus +9 more
TL;DR: TLR2 stimulation by Staphylococcus aureus induces a fast and transient activation of the Rho GTPases Rac1 and Cdc42 in the human monocytic cell line THP-1 and in 293 cells expressing TLR2, and Rac1 controls a second, IκB–independent, pathway to NF-κB activation and is essential in innate immune cell signaling via TLR 2.