J
Jean-Pierre Changeux
Researcher at Collège de France
Publications - 686
Citations - 79845
Jean-Pierre Changeux is an academic researcher from Collège de France. The author has contributed to research in topics: Acetylcholine receptor & Nicotinic agonist. The author has an hindex of 138, co-authored 672 publications receiving 76462 citations. Previous affiliations of Jean-Pierre Changeux include Centre national de la recherche scientifique & Pasteur Institute.
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On the Nature of Allosteric Transitions: A Plausible Model
TL;DR: "It is certain that all bodies whatsoever, though they have no sense, yet they have perception, and whether the body be alterant or alterec, evermore a perception precedeth operation; for else all bodies would be like one to another."
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Allosteric Proteins and Cellular Control Systems
TL;DR: The biological activity of many proteins is controlled by specific metabolites which do not interact directly with the substrates or products of the reactions, and it is suggested that this mechanism plays an essential role in the regulation of metabolic activity.
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Experimental and Theoretical Approaches to Conscious Processing
TL;DR: Converging neuroimaging and neurophysiological data point to objective neural measures of conscious access: late amplification of relevant sensory activity, long-distance cortico-cortical synchronization at beta and gamma frequencies, and "ignition" of a large-scale prefronto-parietal network.
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Conscious, preconscious, and subliminal processing: a testable taxonomy.
Stanislas Dehaene,Jean-Pierre Changeux,Jean-Pierre Changeux,Lionel Naccache,Jérôme Sackur,Claire Sergent +5 more
TL;DR: A taxonomy is proposed that distinguishes between vigilance and access to conscious report, as well as between subliminal, preconscious and conscious processing, and that conscious perception is systematically associated with surges of parieto-frontal activity causing top-down amplification.
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Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine
Marina R. Picciotto,Marina R. Picciotto,Michele Zoli,Roberto Rimondini,Clément Léna,Lisa M. Marubio,Emilio Merlo Pich,Kjell Fuxe,Jean-Pierre Changeux +8 more
TL;DR: In this article, the authors investigated the contribution of the high-affinity neuronal nicotinic acetylcholine receptor to the effects of nicotine on the mesolimbic dopamine system in mice lacking the β2 subunit of this receptor.