Jean-Pierre Mahy

Bio: Jean-Pierre Mahy is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Porphyrin & Heme. The author has an hindex of 29, co-authored 111 publications receiving 2401 citations. Previous affiliations of Jean-Pierre Mahy include University of Paris-Sud & University of Paris.

Metal–organic frameworks: a novel host platform for enzymatic catalysis and detection

Abstract: The use of metal–organic frameworks (MOFs) as immobilization matrices for enzymes as a platform for emerging applications is reported. In addition to an overview of strategies developed to prepare enzyme–MOF biocomposites, the features that render MOFs interesting matrices for bio-immobilization are highlighted along with their potential benefits beyond a solid-state support in the design of innovative biocomposites.

Iron- and manganese-porphyrin catalysed aziridination of alkenes by tosyl- and acyl-iminoiodobenzene

Abstract: N-Substituted aziridines are formed by Fe- or Mn-Porphyrin catalysed reactions of PhlNR compounds (R = tosyl or COCF7) with alkenes; the stereochemical characteristics of these reactions are very different from those of the analogous epoxidation of the alkenes by PhlO.

Enzyme Encapsulation in Mesoporous Metal–Organic Frameworks for Selective Biodegradation of Harmful Dye Molecules

Abstract: Microperoxidase-8, a small, peroxidase-type enzyme was immobilized into nanoparticles of the mesoporous and ultra-stable metal-organic framework (MOF) MIL-101(Cr). The immobilized enzyme fully retained its catalytic activity and exhibited enhanced resistance to acidic conditions. The biocatalyst was reusable and showed a long-term stability. By exploiting the properties of the MOF's framework, we demonstrated, for the first time, that the MOF matrix could act in synergy with the enzyme (Microperoxidase-8) and enhance selectivity the oxidation reaction of dyes. The oxidation rate of the harmful negatively charged dye (methyl orange) was significantly increased after enzyme immobilization, probably as a result of the pre-concentration of the methyl orange reactant owing to a charge matching between this dye and the MOF.

Series of Mn Complexes Based on N‐Centered Ligands and Superoxide – Reactivity in an Anhydrous Medium and SOD‐Like Activity in an Aqueous Medium Correlated to MnII/MnIII Redox Potentials

Abstract: Two crystal structures are described in this article: (a) the structure of a monomeric Mn I I complex with the tridentate N-centered N 3 ligand tris[(1-methyl-2-imidazolyl)methyl]amine (TMIMA) ([Mn I I (TMIMA) 2 ] 2 + ); and(b) the structure of a monomeric Mn I I I complex with the tridentate N-centered N 2 O ligand 2-{[(1-methyl-2-imidazolyl)methyl]amino}phenolate (PI - ) [ 2 ] ([Mn I I I (PI) 2 ] + ) (5). The latter was isolated both in the Mn I I and in the Mn I I I state, although only Mn I I I crystals were successfully grown. They are part of a series of Mn complexes prepared as SOD mimics, namely [Mn(BMPG)(H 2 O)] + (2) {BMPG = N,N-bis[(6-methyl-.2-pyridyl)methyl]glycinate}, [Mn(IPG)(MeOH)] + (3) {IPG = N-[(1-methyl-2-imidazolyl) methyl]-N-(2-pyridylmethyl)glycinate), [Mn(BIG)(H 2 O) 2 ] + (4) {BIG = N,N-bis[(1-methyl-2-imidazolyl)methyl]glycinate}. The reactivity of Mn I I complexes 1 and 2 in an anhydrous medium is described and compared to that of complexes 3 and 4, the data for which was previously published. The cyclic voltammograms of the whole complex series were recorded in an aqueous medium (collidine buffer). Their SOD-like activities were estimated by the McCord-Fridovich test (IC50 with 22 μM cytc Fe I I I : 1.6′0.1 μMolL - 1 for 1, 1.2′0.5 μmolL - 1 for 2, 3.0′0.2 μmolL - 1 for 3, 3.7′0.6 μmolL - 1 for 4, 0.8′0.1 μmolL - 1 for 5). IC50 values were converted into the corresponding kinetic constant k M c C F values. A linear correlation between E a and log(k M c C F ) was obtained, indicating that in this series the conversion to Mn I I I is probably the rate-limiting step. This is of substantial importance for further Mn-SOD mimic design in this series.

Click Chemistry: Diverse Chemical Function from a Few Good Reactions.

Abstract: Examination of nature's favorite molecules reveals a striking preference for making carbon-heteroatom bonds over carbon-carbon bonds-surely no surprise given that carbon dioxide is nature's starting material and that most reactions are performed in water. Nucleic acids, proteins, and polysaccharides are condensation polymers of small subunits stitched together by carbon-heteroatom bonds. Even the 35 or so building blocks from which these crucial molecules are made each contain, at most, six contiguous C-C bonds, except for the three aromatic amino acids. Taking our cue from nature's approach, we address here the development of a set of powerful, highly reliable, and selective reactions for the rapid synthesis of useful new compounds and combinatorial libraries through heteroatom links (C-X-C), an approach we call "click chemistry". Click chemistry is at once defined, enabled, and constrained by a handful of nearly perfect "spring-loaded" reactions. The stringent criteria for a process to earn click chemistry status are described along with examples of the molecular frameworks that are easily made using this spartan, but powerful, synthetic strategy.

Chemistry of Polyvalent Iodine

Abstract: Starting from the early 1990’s, the chemistry of polyvalent iodine organic compounds has experienced an explosive development. This surging interest in iodine compounds is mainly due to the very useful oxidizing properties of polyvalent organic iodine reagents, combined with their benign environmental character and commercial availability. Iodine(III) and iodine(V) derivatives are now routinely used in organic synthesis as reagents for various selective oxidative transformations of complex organic molecules. Several areas of hypervalent organoiodine chemistry have recently attracted especially active interest and research activity. These areas, in particular, include the synthetic applications of 2-iodoxybenzoic acid (IBX) and similar oxidizing reagents based on the iodine(V) derivatives, the development and synthetic use of polymer-supported and recyclable polyvalent iodine reagents, the catalytic applications of organoiodine compounds, and structural studies of complexes and supramolecular assemblies of polyvalent iodine compounds. The chemistry of polyvalent iodine has previously been covered in four books1–4 and several comprehensive review papers.5–17 Numerous reviews on specific classes of polyvalent iodine compounds and their synthetic applications have recently been published.18–61 Most notable are the specialized reviews on [hydroxy(tosyloxy)iodo]benzene,41 the chemistry and synthetic applications of iodonium salts,29,36,38,42,43,46,47,54,55 the chemistry of iodonium ylides,56–58 the chemistry of iminoiodanes,28 hypervalent iodine fluorides,27 electrophilic perfluoroalkylations,44 perfluoroorgano hypervalent iodine compounds,61 the chemistry of benziodoxoles,24,45 polymer-supported hypervalent iodine reagents,30 hypervalent iodine-mediated ring contraction reactions,21 application of hypervalent iodine in the synthesis of heterocycles,25,40 application of hypervalent iodine in the oxidation of phenolic compounds,32,34,50–53,60 oxidation of carbonyl compounds with organohypervalent iodine reagents,37 application of hypervalent iodine in (hetero)biaryl coupling reactions,31 phosphorolytic reactivity of o-iodosylcarboxylates,33 coordination of hypervalent iodine,19 transition metal catalyzed reactions of hypervalent iodine compounds,18 radical reactions of hypervalent iodine,35,39 stereoselective reactions of hypervalent iodine electrophiles,48 catalytic applications of organoiodine compounds,20,49 and synthetic applications of pentavalent iodine reagents.22,23,26,59 The main purpose of the present review is to summarize the data that appeared in the literature following publication of our previous reviews in 1996 and 2002. In addition, a brief introductory discussion of the most important earlier works is provided in each section. The review is organized according to the classes of organic polyvalent iodine compounds with emphasis on their synthetic application. Literature coverage is through July 2008.

Transition Metal-Catalyzed C–H Amination: Scope, Mechanism, and Applications

Abstract: Catalytic transformation of ubiquitous C–H bonds into valuable C–N bonds offers an efficient synthetic approach to construct N-functionalized molecules. Over the last few decades, transition metal catalysis has been repeatedly proven to be a powerful tool for the direct conversion of cheap hydrocarbons to synthetically versatile amino-containing compounds. This Review comprehensively highlights recent advances in intra- and intermolecular C–H amination reactions utilizing late transition metal-based catalysts. Initial discovery, mechanistic study, and additional applications were categorized on the basis of the mechanistic scaffolds and types of reactions. Reactivity and selectivity of novel systems are discussed in three sections, with each being defined by a proposed working mode.

Transition Metal-Mediated Cycloaddition Reactions

Abstract: 5.7. [32π + 32σ] Cycloadditions 74 5.8. [44π + 22π] Cycloadditions 75 6. Seven-Membered Ring Formation 78 6.1. [44π + 32σ] Cycloadditions 78 6.2. [52π+2σ + 22π] Cycloadditions 79 7. Eight-Membered Ring Formation 79 7.1. [22π + 22π + 22π + 22π] Cycloadditions 80 7.2. [44π + 22π + 22π] Cycloadditions 80 7.3. [44π + 44π] Cycloadditions 81 7.4. [66π + 22π] Cycloadditions 83 8. Ten-Membered Ring Formation 85 9. Conclusion and Remarks 87