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Author

Jean-Pierre Robin

Bio: Jean-Pierre Robin is an academic researcher from Geelong Football Club. The author has contributed to research in topics: Side chain & Moiety. The author has an hindex of 3, co-authored 8 publications receiving 33 citations.

Papers
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Patent
25 May 2006
TL;DR: In this article, a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy, is presented, which comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor.
Abstract: The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and functionalization are entirely preformed. The invention also concerns a natural, synthetic or semi-synthetic harringtonines including their tautomeric forms and their salts of the following formula: wherein n=2 (i.e. harringtonine) or n=3 (i.e. homoharringtonine), in which the total content of impurities, possibly including enantiomeric forms, is lower than 1%, and/or the content of the major impurity is lower than 0.9%, and/or the chromatographic assay exhibits a harringtonines content higher than 97.5%.

11 citations

Patent
04 Jun 2004
TL;DR: In this paper, the present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative, and is related to the present paper.
Abstract: The present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative.

11 citations

Patent
25 Oct 1996
TL;DR: In this article, the authors proposed a new intermediary for the hemisynthesis of taxanes and their preparation processes, which enables to obtain a product such as PACLITAXELTM in only five steps from products available in the market, compared to nine steps for processes of the prior art.
Abstract: The present invention relates to new intermediaries for the hemisynthesis of taxanes and their preparation processes. It relates particularly to derivatives of oxazolidines or oxazolidinones, as well as to new derivatives of baccatine III. The general process for the synthesis of taxanes according to the invention enables to obtain a product such as PACLITAXELTM in only five steps from products available in the market, compared to nine steps in general, for processes of the prior art.

8 citations

Patent
16 Mar 1999
TL;DR: In this paper, a new general process for asymetric hemisynthesis of harringtonines and their analogs, that are alcaloids used in chimiotherapy, is described.
Abstract: The present invention concerns a new general process for asymetric hemisynthesis of harringtonines and their analogs, that are alcaloids used in chimiotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and fonctionalization are entirely preformed.

3 citations

Patent
27 Oct 1995
TL;DR: In this article, the authors present an invention concerne de nouveaux intermediaires for l'hemisynthese de taxanes and leurs procedes de preparation.
Abstract: La presente invention concerne de nouveaux intermediaires pour l'hemisynthese de taxanes et leurs procedes de preparation. Il s'agit notamment de derives d'oxazolidines ou d'oxazolidinones, ainsi que de nouveaux derives de la baccatine Ill. Le procede general de synthese des taxanes selon l'invention permet d'obtenir un produit tel que le PACLITAXEL en seulement cinq etapes a partir de produits disponibles dans le commerce, contre generalement neuf etapes pour les procedes de l'etat de la technique.

Cited by
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Patent
06 Jul 2012
TL;DR: In this article, a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture which is a fish oil or which is derived from fish oil is presented.
Abstract: The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture which is a fish oil or which is derived from fish oil, which process comprises the steps of: (i) purifying the feed mixture in a chromatographic separation step, to obtain a first intermediate product; and (ii) purifying the first intermediate product obtained in (i) in a simulated or actual moving bed chromatographic separation step, to obtain a second intermediate product; and (iii) purifying the second intermediate product obtained in (ii) in a simulated or actual moving bed chromatographic separation step, to obtain the PUFA product; wherein an aqueous organic solvent is used as eluent in each separation step; saturated and/or monounsaturated fatty acids present in the feed mixture are removed in the first separation step; the PUFA product is separated from different components of the feed mixture in steps (ii) and (iii); and the PUFA product obtained in the third separation step contains EPA or an EPA derivative in an amount greater than 90 wt%.

14 citations

Patent
03 Mar 2009
TL;DR: In this paper, the authors provided novel cephalotaxus esters, syntheses thereof, and intermediates for the treatment of proliferative diseases (e.g., benign neoplasm, cancer, inflammatory disease, autoimmune disease, diabetic retinopathy) and infectious disease.
Abstract: The present invention provides novel cephalotaxus esters, syntheses thereof, and intermediates thereto. The invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of using said compounds or compositions in the treatment of proliferative diseases (e.g., benign neoplasm, cancer, inflammatory disease, autoimmune disease, diabetic retinopathy) and infectious disease. The invention further provides methods of using said compounds or compositions in the treatment of multidrug resistant cancer.

13 citations

Patent
24 Dec 2010
TL;DR: In this paper, a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture, which process comprises introducing the feed mixture to a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous alcohol, was presented.
Abstract: The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product, from a feed mixture, which process comprises introducing the feed mixture to a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous alcohol, wherein the apparatus has a plurality of zones comprising at least a first zone and second zone, each zone having an extract stream and a raffinate stream from which liquid can be collected from said plurality of linked chromatography columns, and wherein (a) a raffinate stream containing the PUFA product together with more polar components is collected from a column in the first zone and introduced to a nonadjacent column in the second zone, and/or (b) an extract stream containing the PUFA product together with less polar components is collected from a column in the second zone and introduced to a nonadjacent column in the first zone, said PUFA product being separated from different components of the feed mixture in each zone.

11 citations

Patent
25 May 2006
TL;DR: In this article, a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy, is presented, which comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor.
Abstract: The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and functionalization are entirely preformed. The invention also concerns a natural, synthetic or semi-synthetic harringtonines including their tautomeric forms and their salts of the following formula: wherein n=2 (i.e. harringtonine) or n=3 (i.e. homoharringtonine), in which the total content of impurities, possibly including enantiomeric forms, is lower than 1%, and/or the content of the major impurity is lower than 0.9%, and/or the chromatographic assay exhibits a harringtonines content higher than 97.5%.

11 citations

Patent
04 Jun 2004
TL;DR: In this paper, the present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative, and is related to the present paper.
Abstract: The present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative.

11 citations