Author
Jean T. Corbett
Bio: Jean T. Corbett is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Phthalate & Radical. The author has an hindex of 26, co-authored 46 publications receiving 1890 citations.
Papers
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TL;DR: Radioactivity from carbonyl-labeled DEHP did not associate with purified protein, RNA or DNA from rat liver in vivo, and the apparent binding from DEHP and MEHP was not exchangeable, but was not proven to be covalent.
Abstract: The recent long-term carcinogenesis bioassay of di(2-ethylhexyl) phthalate (DEHP) in rats and mice reported by the National Toxicology Program was the first such bioassay to implicate DEHP as a hep...
194 citations
TL;DR: In vivo lipid‐derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide is investigated, using rats treated with intratracheal instillation of LPS as a model for ARDS.
Abstract: Intratracheal instillation of lipopolysaccharide (LPS) activates alveolar macrophages and infiltration of neutrophils, causing lung injury/acute respiratory distress syndrome. Free radicals are a s...
159 citations
TL;DR: In this article, the polychlorinated biphenyl (PCB) compositions of Aroclors 1248, 1254 and 1260 have been determined using gas chromatography.
137 citations
TL;DR: Results, for the first time, suggest that leptin action in macrophages of the steatotic liver, through induction of iNOS and NADPH oxidase, causes peroxynitrite-mediated oxidative stress thus activating Kupffer cells.
119 citations
TL;DR: A rapid, dose-dependent effect of TCDD, was the elevation of levels of organic-soluble fluorescent pigment in the heart, which was found to match a previously characterized fraction of lipofuscins in fluorescence spectrum and chromatographic properties.
93 citations
Cited by
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28 Jul 2005
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。
18,940 citations
TL;DR: The toxicity of halogenated aromatic hydrocarbons appears to be due to the sustained expression of a normal cellular regulatory system, of which the author was previously unaware.
Abstract: In this review, we have examined the biochemical and toxic responses produced by halogenated aromatic hydrocarbons and have tried to develop a model for their mechanism of action. These compounds bind to a cellular receptor and evoke a sustained pleiotropic response. In many tissues this response consists of the expression of a battery of enzymes which are, for the most part, involved in drug metabolism, but in other tissues, those which develop toxicity, an additional set of genes is expressed which effects cellular involution, division, and/or differentiation. The toxicity of these compounds appears to be due to the sustained expression of a normal cellular regulatory system, of which we were previously unaware. In future investigations it is hoped that we will learn the nature and physiologic role of this regulatory system. Only then can we hope to understand the mechanism of toxicity of these compounds.
2,536 citations
TL;DR: These various principles will be illustrated by considering several thiol compounds by scavenging biologically important reactive oxygen species by preventing their formation, or by repairing the damage they do.
1,772 citations
TL;DR: Analysis of the results of laboratory animal and wildlife studies suggests that the predictive value of TEQs for PCBs may be both species- and response-dependent because both additive and nonadditive (antagonistic) interactions have been observed with PCB mixtures.
Abstract: Commercial polychlorinated biphenyls (PCBs) and environmental extracts contain complex mixtures of congeners that can be unequivocally identified and quantitated. Some PCB mixtures elicit a spectrum of biochemical and toxic responses in humans and laboratory animals and many of these effects resemble those caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related halogenated aromatic hydrocarbons, which act through the aryl hydrocarbon (Ah)-receptor signal transduction pathway. Structure-activity relationships developed for PCB congeners and metabolites have demonstrated that several structural classes of compounds exhibit diverse biochemical and toxic responses. Structure-toxicity studies suggest that the coplanar PCBs, namely, 3,3',4,4'-tetrachlorobiphenyl (tetraCB), 3,3',4,4',5-pentaCB, 3,3',4,4',5,5'-hexaCB, and their monoortho analogs are Ah-receptor agonists and contribute significantly to the toxicity of the PCB mixtures. Previous studies with TCDD and structurally related compounds ...
1,724 citations
TL;DR: The main goal of the present paper is to review the fluorescence methodologies that have been used for detecting ROS in biological and non-biological media.
1,536 citations