Jean-Yves Fagon

TL;DR: In this paper, kidney biopsy was performed immediately post-mortem in consecutive patients who died of septic shock and the results showed that acute tubular lesion intensity correlated with blood lactate concentration; intense infiltration by leukocytes, mainly monocytic, in glomeruli and interstitial capillaries; presence of tubular cell apoptosis proved by the presence of apoptotic bodies significantly more frequently than in controls and confirmed by TUNEL and activated caspase-3 staining.

TL;DR: Findings suggest that determination of the number and the type of organ dysfunctions and infection offers a clear and reliable method for characterizing ICU patients and requires to be validated in other institutions.

TL;DR: The results from two methodologically identical double-blind studies indicate that telavancin is noninferior to vancomycin based on clinical response in the treatment of hospital-acquired pneumonia due to Gram-positive pathogens.

TL;DR: Ulasonographic-based determination of hemidiaphragm excursions in patients requiring prolonged mechanical ventilation after cardiac surgery may help identify those with and without severe diaphragmatic dysfunction as defined by the Gilbert index.

TL;DR: Candidemia is late-onset ICU-acquired infection associated with high mortality, and the prescribed curative antifungal agent was active in vitro against the responsible identified strain.