J
Jeff Swensen
Researcher at University of Utah
Publications - 32
Citations - 8877
Jeff Swensen is an academic researcher from University of Utah. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 14, co-authored 23 publications receiving 8584 citations. Previous affiliations of Jeff Swensen include ARUP Laboratories & Myriad Genetics.
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Journal ArticleDOI
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
Yoshio Miki,Jeff Swensen,Donna M Shattuck-Eidens,P. Andrew Futreal,Keith D Harshman,Sean V. Tavtigian,Qingyun Liu,Charles Cochran,L. Michelle Bennett,Wei Ding,Russell Bell,Judith Rosenthal,Charles E. Hussey,Thanh Tran,Melody McClure,Cheryl Frye,Tom Hattier,Robert Phelps,Astrid Haugen-Strano,Harold Katcher,Kazuko Yakumo,Zahra Gholami,Daniel Shaffer,Steven Stone,Steven Bayer,Christian Wray,Robert Bogden,Priya Dayananth,John R. Ward,Patricia N. Tonin,Steven A. Narod,Pam K. Bristow,Frank H. Norris,Leah M. Helvering,Paul Morrison,Paul Robert Rosteck,Mei Lai,J. Carl Barrett,Cathryn M. Lewis,Susan L. Neuhausen,Lisa A. Cannon-Albright,David E. Goldgar,Roger W. Wiseman,Alexander Kamb,Mark H. Skolnick +44 more
TL;DR: A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods.
Journal ArticleDOI
BRCA1 mutations in primary breast and ovarian carcinomas
P. Andrew Futreal,Qingyun Liu,Donna M Shattuck-Eidens,Charles Cochran,Keith D Harshman,Sean V. Tavtigian,L. Michelle Bennett,Astrid Haugen-Strano,Jeff Swensen,Yoshio Miki,Ken Eddington,Melody McClure,Cheryl Frye,Jane Weaver-Feldhaus,Wei Ding,Zahra Gholami,Peter Söderkvist,Lori A. Terry,Suresh C. Jhanwar,Andrew Berchuck,J. Dirk Iglehart,Jeffrey R. Marks,Dennis G. Ballinger,J. Cari Barrett,Mark H. Skolnick,Mark H. Skolnick,Alexander Kamb,Roger W. Wiseman +27 more
TL;DR: Results suggest that mutation of BRCA1 may not be critical in the development of the majority of breast and ovarian cancers that arise in the absence of a mutant germline allele.
Journal ArticleDOI
A candidate prostate cancer susceptibility gene at chromosome 17p.
Sean V. Tavtigian,Jacques Simard,David H. F. Teng,Vicki Abtin,Michelle Baumgard,Audrey Beck,Nicola J. Camp,Nicola J. Camp,Arlene Carillo,Yang Chen,Priya Dayananth,Marc Desrochers,Martine Dumont,James M. Farnham,David A. Frank,Cheryl Frye,Siavash Ghaffari,Jamila Gupte,Rong Hu,Diana Iliev,Teresa Janecki,Edward N. Kort,Kirsten Laity,Amber Leavitt,Gilles Leblanc,Jodi Mcarthur-Morrison,Amy Pederson,Brandon Penn,Kelly T. Peterson,Julia Reid,Sam Richards,Marianne Schroeder,Richard D. Smith,Sarah C. Snyder,Brad Swedlund,Jeff Swensen,Alun Thomas,Martine Tranchant,Ann Marie Woodland,Fernand Labrie,Mark H. Skolnick,Susan L. Neuhausen,Johanna M. Rommens,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright +44 more
TL;DR: A genome-wide scan of large, high-risk pedigrees from Utah has provided evidence for linkage to a locus on chromosome 17p, identifying a gene, ELAC2, harboring mutations (including a frameshift and a nonconservative missense change) that segregate with prostate cancer in two pedigree.
Journal ArticleDOI
Recurrent BRCA2 6174delT mutations in Ashkenazi Jewish women affected by breast cancer.
Susan L. Neuhausen,Teresa Gilewski,Larry Norton,T.D. Tran,Peter McGuire,Jeff Swensen,Heather Hampel,Patrick I. Borgen,Karen T. Brown,Mark H. Skolnick,Mark H. Skolnick,Donna M Shattuck-Eidens,Suresh C. Jhanwar,David E. Goldgar,Kenneth Offit +14 more
TL;DR: The results of this report suggest that a recurrent mutation of BRCA1 and a recurrent mutations ofBRCA2 together may account for over a quarter of all early-onset breast cancer cases and two thirds of early-ONSet breastcancer in the setting of a personal or family history of ovarian cancer in Ashkenazi Jewish women.
Journal Article
The Human Prohibitin Gene Located on Chromosome 17q21 Is Mutated in Sporadic Breast Cancer
Takaaki Sato,Hiroko Saito,Jeff Swensen,Arnold Olifant,Carla N. Wood,David B. Danner,Takashi Sakamoto,Ken-ichi Takita,Fujio Kasumi,Yoshio Miki,Mark H. Skolnick,Yusuke Nakamura +11 more
TL;DR: DNA sequence analysis of 2 exons in this gene in 23 sporadic breast cancers, which showed loss of heterozygosity on the long arm of chromosome 17 or developed in patients 35 years old or younger, identified 4 cases of somatic mutation.