J
Jeffery A. Porter
Researcher at Novartis
Publications - 46
Citations - 17266
Jeffery A. Porter is an academic researcher from Novartis. The author has contributed to research in topics: Sonic hedgehog & Hedgehog signaling pathway. The author has an hindex of 37, co-authored 45 publications receiving 16017 citations. Previous affiliations of Jeffery A. Porter include Johns Hopkins University School of Medicine & Johns Hopkins University.
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Journal ArticleDOI
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
Shih Min A Huang,Yuji Mishina,Shanming Liu,Atwood K. Cheung,Frank Stegmeier,Gregory A. Michaud,Olga Charlat,Elizabeth Wiellette,Yue Zhang,Stephanie Wiessner,Marc Hild,Xiaoying Shi,Christine D. Wilson,Craig Mickanin,Vic E. Myer,Aleem Fazal,Ronald Tomlinson,Fabrizio C. Serluca,Wenlin Shao,Hong Cheng,Michael Shultz,Christina Rau,Markus Schirle,Judith Schlegl,Sonja Ghidelli,Stephen Fawell,Chris Lu,Daniel Curtis,Marc W. Kirschner,Christoph Lengauer,Peter Finan,John A. Tallarico,Tewis Bouwmeester,Jeffery A. Porter,Andreas Bauer,Feng Cong +35 more
TL;DR: This study uses a chemical genetic screen to identify a small molecule, XAV939, which selectively inhibits β-catenin-mediated transcription and reveals new mechanistic insights into the regulation of axin protein homeostasis, which presents new avenues for targeted Wnt pathway therapies.
Journal ArticleDOI
Directed Differentiation of Embryonic Stem Cells into Motor Neurons
TL;DR: It is shown that developmentally relevant signaling factors can induce mouse embryonic stem cells to differentiate into spinal progenitor cells, and subsequently into motor neurons, through a pathway recapitulating that used in vivo.
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Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development
TL;DR: It is reported that cholesterol is the lipophilic moiety covalently attached to the amino- terminal signaling domain during autoprocessing and that the carboxyl-terminal domain acts as an intramolecular cholesterol transferase.
Journal ArticleDOI
Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
Henk Roelink,Jeffery A. Porter,C Chiang,Y Tanabe,D.T Chang,Philip A. Beachy,Thomas M. Jessell +6 more
TL;DR: The results suggest that the induction of floor plate cells and motor neurons by the notochord in vivo is mediated by exposure of neural plate cells to different concentrations of the amino-terminal product of SHH autoproteolytic cleavage.
Journal ArticleDOI
Teratogen-mediated inhibition of target tissue response to Shh signaling.
TL;DR: Veratrum alkaloids and distal inhibitors of cholesterol biosynthesis have been studied for more than 30 years as potent teratogens but it is shown that these compounds specifically block the Sonic hedgehog (Shh) signaling pathway.