J
Jeffrey D. Esko
Researcher at University of California, San Diego
Publications - 418
Citations - 40092
Jeffrey D. Esko is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Heparan sulfate & Glycobiology. The author has an hindex of 88, co-authored 400 publications receiving 36511 citations. Previous affiliations of Jeffrey D. Esko include Hebrew University of Jerusalem & Georgia Institute of Technology.
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Book
Essentials of Glycobiology
Ajit Varki,Richard D. Cummings,Jeffrey D. Esko,Hudson H. Freeze,Pamela Stanley,Carolyn R. Bertozzi,Gerald W. Hart,Marilynn E. Etzler +7 more
TL;DR: General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans biosynthesis, metabolism, and function.
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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
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Heparan sulphate proteoglycans fine-tune mammalian physiology
TL;DR: Heparan sulphate proteoglycans reside on the plasma membrane of all animal cells studied so far and are a major component of extracellular matrices, which affects metabolism, transport, information transfer, support and regulation in all organ systems.
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Order out of chaos: assembly of ligand binding sites in heparan sulfate.
Jeffrey D. Esko,Scott B. Selleck +1 more
TL;DR: A review of recent developments in the biosynthetic apparatus of metazoan organisms provides a resource for investigators interested in the incredible diversity and specificity of this process.
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Heparan Sulfate Proteoglycans
TL;DR: Changing views on the specificity of protein-heparan sulfate binding and the activity of HSPGs as receptors and coreceptors are discussed.