J
Jeffrey M. Friedman
Researcher at Rockefeller University
Publications - 218
Citations - 64673
Jeffrey M. Friedman is an academic researcher from Rockefeller University. The author has contributed to research in topics: Leptin & Leptin receptor. The author has an hindex of 89, co-authored 209 publications receiving 61573 citations. Previous affiliations of Jeffrey M. Friedman include University of British Columbia & Howard Hughes Medical Institute.
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Journal ArticleDOI
Positional cloning of the mouse obese gene and its human homologue
Yiying Zhang,Ricardo Proenca,Ricardo Proenca,Margherita Maffei,Marisa Barone,Marisa Barone,Lori Leopold,Lori Leopold,Jeffrey M. Friedman,Jeffrey M. Friedman +9 more
TL;DR: The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.
Journal ArticleDOI
Leptin and the regulation of body weight in mammals
TL;DR: The role of leptin in the control of body weight and its relevance to the pathogenesis of obesity are reviewed.
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Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Jeffrey L. Halaas,Gajiwala Ketan,Margherita Maffei,Steven L. Cohen,Brian T. Chait,Daniel Rabinowitz,Roger Lallone,Stephen K. Burley,Jeffrey M. Friedman +8 more
TL;DR: Injection of wild-type mice twice daily with the mouse protein resulted in a sustained 12 percent weight loss, decreased food intake, and a reduction of body fat from 12.2 to 0.7 percent, suggesting that the OB protein serves an endocrine function to regulate body fat stores.
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Leptin levels in human and rodent : Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
Margherita Maffei,Jeffrey L. Halaas,Eric Ravussin,Richard E. Pratley,Gwo-Hwa Lee,Gwo-Hwa Lee,Yan Zhang,Yan Zhang,Hong Fei,S. Kim,R. Lallone,S. Ranganathan,Philip A. Kern,Philip A. Kern,Jeffrey M. Friedman,Jeffrey M. Friedman +15 more
TL;DR: Weight loss due to food restriction was associated with a decrease in plasma leptin in samples from mice and obese humans, suggesting differences in its secretion rate from fat.
Journal ArticleDOI
Abnormal splicing of the leptin receptor in diabetic mice
Gwo-Hwa Lee,Gwo-Hwa Lee,Ricardo Proenca,Ricardo Proenca,Jason M. Montez,K. M. Carroll,J. G. Darvishzadeh,Jaeeon Lee,Jeffrey M. Friedman,Jeffrey M. Friedman +9 more
TL;DR: A leptin receptor was recently cloned from choroid plexus and shown to map to the same 6-cM interval on mouse chromosome 4 as db8, suggesting that the weight-reducing effects of leptin may be mediated by signal transduction through a leptin receptor in the hypothalamus.