J
Jeffrey W. Bode
Researcher at ETH Zurich
Publications - 325
Citations - 14950
Jeffrey W. Bode is an academic researcher from ETH Zurich. The author has contributed to research in topics: Catalysis & Enantioselective synthesis. The author has an hindex of 60, co-authored 310 publications receiving 13088 citations. Previous affiliations of Jeffrey W. Bode include Nagoya University & University of Pennsylvania.
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Rethinking amide bond synthesis
TL;DR: A new generation of amide-forming reactions are reviewed and summarize their potential application to current synthetic challenges, including the development of catalytic amide formation, the synthesis of therapeutic peptides and the preparation of modified peptide and proteins.
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N-Heterocyclic Carbene-Catalyzed Generation of Homoenolates: γ-Butyrolactones by Direct Annulations of Enals and Aldehydes
TL;DR: This process demonstrates an unprecedented reaction mode for the generation of nucleophilic carbanions with a multifunctional organocatalyst under exceptionally mild and convenient reaction conditions.
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On the Mechanism of N-Heterocyclic Carbene-Catalyzed Reactions Involving Acyl Azoliums
TL;DR: This Account addresses the mechanistic inquiries about the characterization of the unsaturated acyl triazolium species and its kinetic profile under catalytically relevant conditions and provides explanations for the requirement and effect of the N-mesityl group in NHC catalysis based on detailed experimental data within given reactions or conditions.
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Highly enantioselective azadiene Diels-Alder reactions catalyzed by chiral N-heterocyclic carbenes.
TL;DR: In contrast to uncatalyzed variants, this organocatalytic process proceeds at room temperature without stoichiometric reagents, producing synthetically valuable, enantiomerically pure cis-3,4-disubstituted dihydropyridinone products.