Showing papers by "Jeffrey W. Kysar published in 2019"
TL;DR: Of all engineering materials, polymers and polymer-based composites are best able to mimic the tissue-level mechanical behavior of the native leaflet, and these material models have been incorporated into computational models for the optimization of valve geometry, with the goal of minimizing internal stresses and improving durability.
55 citations
TL;DR: It is confirmed that for drug dissolved in saline, multiple small perforations can effectively enhance diffusion, however, for drug dissolve in P407, larger perforation are necessary.
15 citations
Patent•
11 Jul 2019
TL;DR: In this paper, a cleavable microneedle for delivery of therapeutic agent is described, where the needle includes a longitudinal body having a detachable portion that comprises at least one therapeutic agent.
Abstract: The disclosed subject matter relates to a cleavable microneedle for delivery of therapeutic agent, wherein the needle includes a longitudinal body having a detachable portion that comprises at least one therapeutic agent. The microneedle may be configured to administer the therapeutic agent to the inner ear of a subject. Also disclosed is a method for preparing a microneedle using two-photon polymerization lithography.
4 citations
TL;DR: In this article, a numerical investigation of wedge indentation into a monazite (LaPO4) single crystal is carried out to obtain the asymptotic field solution associated with the moving contact point singularities.
4 citations
Patent•
24 Oct 2019
TL;DR: An apparatus for controlled perforation and aspiration of the inner ear having a distal portion including a plurality of apices and valleys therebetween defining a serrated blades is described in this article.
Abstract: An apparatus for controlled perforation and aspiration of the inner ear having a distal portion including a plurality of apices and a plurality of valleys therebetween defining a plurality of serrated blades.