J
Jennielee Mia
Researcher at University of California, Davis
Publications - 2
Citations - 31
Jennielee Mia is an academic researcher from University of California, Davis. The author has contributed to research in topics: Centrosome & Microtubule. The author has an hindex of 2, co-authored 2 publications receiving 7 citations.
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Journal ArticleDOI
Condensation of pericentrin proteins in human cells illuminates phase separation in centrosome assembly
Xueer Jiang,Dac Bang Tam Ho,Karan Mahe,Jennielee Mia,Guadalupe Sepulveda,Mark Antkowiak,Linhao Jiang,Soichiro Yamada,Li-En Jao +8 more
TL;DR: This article found that the N-terminal portion of pericentrin, enriched with conserved coiled-coils (CCs) and low-complexity regions (LCRs), phase separates into dynamic condensates that selectively recruit PCM proteins and nucleate microtubules in cells.
Posted ContentDOI
Condensation of pericentrin proteins in human cells illuminates phase separation in centrosome assembly
Xueer Jiang,Dac Bang Tam Ho,Karan Mahe,Jennielee Mia,Guadalupe Sepulveda,Mark Antkowiak,Soichiro Yamada,Li-En Jao +7 more
TL;DR: It is found that endogenously expressed pericentrin (PCNT), a conserved PCM scaffold protein, condenses into liquid-like granules during early mitosis in cultured human cells and the N-terminal segment of PCNT, enriched with conserved coiled-coils and low-complexity regions (LCRs), undergoes phase separation.