J
Jennifer A. Prescher
Researcher at University of California, Irvine
Publications - 92
Citations - 12266
Jennifer A. Prescher is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Bioorthogonal chemistry & Bioluminescence. The author has an hindex of 36, co-authored 79 publications receiving 10758 citations. Previous affiliations of Jennifer A. Prescher include Stanford University & University of California, Berkeley.
Papers
More filters
Journal ArticleDOI
A Strain-Promoted [3 + 2] Azide−Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems
TL;DR: A strain-promoted [3 + 2] cycloaddition between cyclooctynes and azides that proceeds under physiological conditions without the need for a catalyst was demonstrated by selective modification of biomolecules in vitro and on living cells, with no apparent toxicity.
Journal ArticleDOI
Copper-free click chemistry for dynamic in vivo imaging
Jeremy M. Baskin,Jennifer A. Prescher,Scott T. Laughlin,Nicholas J. Agard,Pamela V. Chang,Isaac A. Miller,Anderson Lo,Julian A. Codelli,Carolyn R. Bertozzi +8 more
TL;DR: A Cu-free variant of click chemistry that can label biomolecules rapidly and selectively in living systems, overcoming the intrinsic toxicity of the canonical Cu-catalyzed reaction is reported.
Journal ArticleDOI
Chemistry in living systems.
TL;DR: This review highlights the development of bioorthogonal chemical reporters and reactions and their application in living systems.
Journal ArticleDOI
Chemical remodelling of cell surfaces in living animals
TL;DR: It is demonstrated that the Staudinger ligation can be executed in living animals, enabling the chemical modification of cells within their native environment and may enable therapeutic targeting and non-invasive imaging of changes in glycosylation during disease progression.
Journal ArticleDOI
A Comparative Study of Bioorthogonal Reactions with Azides
TL;DR: Both the Staudinger ligation and the strain-promoted [3 + 2] cycloaddition using optimized cyclooctynes were effective for tagging azides on live cells and provided a guide for biologists in choosing a suitable ligation chemistry.