J
Jennifer B. Paulson
Researcher at University of Minnesota
Publications - 5
Citations - 2436
Jennifer B. Paulson is an academic researcher from University of Minnesota. The author has contributed to research in topics: Transgene & Genetically modified mouse. The author has an hindex of 4, co-authored 5 publications receiving 2184 citations.
Papers
More filters
Journal ArticleDOI
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
Karen S. SantaCruz,Jada Lewis,Tara L. Spires,Jennifer B. Paulson,Linda Kotilinek,Martin Ingelsson,A. Guimaraes,Michael DeTure,Martin Ramsden,Eileen McGowan,Colleen L. Forster,Mei Yue,Jennifer D. Orne,Chris Janus,Ami Mariash,Michael A. Kuskowski,Bradley T. Hyman,Mike Hutton,Karen H. Ashe +18 more
TL;DR: NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy, and after the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to the authors' surprise, NFTs continued to accumulate.
Journal ArticleDOI
Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)
Martin Ramsden,Linda Kotilinek,Colleen L. Forster,Jennifer B. Paulson,Eileen McGowan,Karen S. SantaCruz,Aaron Guimaraes,Mei Yue,Jada Lewis,George A. Carlson,Mike Hutton,Karen H. Ashe +11 more
TL;DR: A novel transgenic mouse that closely mimics human tauopathy is described and may represent an important model for the future study of tau-related neurodegenerative disease.
Journal ArticleDOI
Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease.
Jennifer B. Paulson,Martin Ramsden,Colleen L. Forster,Mathew A. Sherman,Eileen McGowan,Karen H. Ashe,Karen H. Ashe +6 more
TL;DR: A novel transgenic mouse model, rTg3696AB, is presented, which expresses human APP(NLI) and tau(P301L) driven by the CaMKII promoter system and is regulatable, permitting temporal control of gene expression and the investigation of transgene suppression.
Journal ArticleDOI
Characterization of a Novel Mouse Model of Alzheimer’s Disease—Amyloid Pathology and Unique β-Amyloid Oligomer Profile
Peng Liu,Jennifer B. Paulson,Colleen L. Forster,Samantha L. Shapiro,Karen H. Ashe,Kathleen R. Zahs +5 more
TL;DR: The generation and characterization of a novel transgenic mouse model of Aβ toxicity and expression of the tetracycline transactivator resulted in reduced brain weight and smaller dentate-gyrus size indicate that rTg9191 mice may serve as a model for studying the neurological effects of the fibrillar Aβ assemblies in situ.