Jennifer Bruce

TL;DR: It is shown that TDP-43 is the major disease protein in both frontotemporal lobar degeneration with ubiquitin-positive inclusions and amyotrophic lateral sclerosis.

TL;DR: MT-stabilizing drugs could have therapeutic potential for treating neurodegenerative tauopathies by offsetting losses of tau function that result from the sequestration of this MT-st stabilizing protein into filamentous inclusions.

TL;DR: Examination of tissue sections from FTLD-U brains stained with anti-ubiquitin antibodies revealed heterogeneity in the morphological characteristics of pathological inclusions among subsets of cases, suggesting that frontotemporal lobar degeneration with ubiquitin-positive inclusions is pathologically heterogeneous.

TL;DR: The results indicate that a selective loss of all six tau isoforms, but not tau mRNA, occurs in DLDH and HDDD2 brains compared to normal control and Alzheimer's disease brains, suggesting that the level of tau protein may be controlled posttranscriptionally, at thelevel of either translation or mRNA stability.

TL;DR: Changes in immunoreactivities to NF-P and NF-dP were observed only in the perikarya of large neurons and were closely associated with chromatolytic changes in these neurons.