J
Jennifer J. Trowbridge
Researcher at Harvard University
Publications - 60
Citations - 2361
Jennifer J. Trowbridge is an academic researcher from Harvard University. The author has contributed to research in topics: Haematopoiesis & Stem cell. The author has an hindex of 22, co-authored 42 publications receiving 1950 citations. Previous affiliations of Jennifer J. Trowbridge include Howard Hughes Medical Institute & University of Western Ontario.
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Journal ArticleDOI
DNA Methyltransferase 1 Is Essential for and Uniquely Regulates Hematopoietic Stem and Progenitor Cells
Jennifer J. Trowbridge,Jonathan W. Snow,Jonghwan Kim,Jonghwan Kim,Stuart H. Orkin,Stuart H. Orkin +5 more
TL;DR: A unique and critical role is established for Dnmt1 in the primitive hematopoietic compartment of HSCs and multipotent and lineage-restricted progenitors, suggesting that DnMT1 differentially controls these populations.
Journal ArticleDOI
Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation
Jennifer J. Trowbridge,Anargyros Xenocostas,Anargyros Xenocostas,Randall T. Moon,Mickie Bhatia,Mickie Bhatia,Mickie Bhatia +6 more
TL;DR: It is shown that hematopoietic repopulation can be augmented by administration of a glycogen synthase kinase-3 (GSK-3) inhibitor to recipient mice transplanted with mouse or human HSCs, and suggested that administration of GSK-3 inhibitors may provide a clinical means to directly enhance the repopulating capacity of transplanted H SCs.
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Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease
Aaron Burberry,Aaron Burberry,Naoki Suzuki,Naoki Suzuki,Jin Yuan Wang,Jin Yuan Wang,Rob Moccia,Rob Moccia,Daniel A. Mordes,Daniel A. Mordes,Morag Stewart,Morag Stewart,Satomi Suzuki-Uematsu,Satomi Suzuki-Uematsu,Sulagna Ghosh,Sulagna Ghosh,Ajay K. Singh,Ajay K. Singh,Florian T. Merkle,Florian T. Merkle,Kathryn Koszka,Kathryn Koszka,Quan Zhen Li,Leonard I. Zon,Derrick J. Rossi,Derrick J. Rossi,Jennifer J. Trowbridge,Luigi D. Notarangelo,Luigi D. Notarangelo,Kevin Eggan,Kevin Eggan +30 more
TL;DR: It is shown that mice harboring loss-of-function mutations in the ortholog of C9ORF72 develop splenomegaly, neutrophilia, thrombocytopenia, increased expression of inflammatory cytokines, and severe autoimmunity, ultimately leading to a high mortality rate.
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Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A
Jian Xu,Daniel E. Bauer,Marc A. Kerenyi,Thuy D. Vo,Serena Hou,Yu Jung Hsu,Huilan Yao,Jennifer J. Trowbridge,Gail Mandel,Stuart H. Orkin,Stuart H. Orkin +10 more
TL;DR: It is shown that the lysine-specific demethylase 1 and repressor element-1 silencing transcription factor corepressor 1 (LSD1/CoREST) histone dem methylase complex interacts with BCL11A and is required for full developmental silencing of mouse embryonic β-like globin genes and human γ-globin genes in adult erythroid cells in vivo.
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Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration
TL;DR: This study demonstrates that downstream activation of the Hedgehog (Hh) signaling pathway induces cycling and expansion of primitive bone marrow hematopoietic cells under homeostatic conditions and during acute regeneration.