J
Jennifer Lippincott-Schwartz
Researcher at Howard Hughes Medical Institute
Publications - 62
Citations - 5062
Jennifer Lippincott-Schwartz is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Lipid droplet & Golgi apparatus. The author has an hindex of 21, co-authored 62 publications receiving 2992 citations. Previous affiliations of Jennifer Lippincott-Schwartz include United States Department of Health and Human Services & Janelia Farm Research Campus.
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Journal ArticleDOI
Applying systems-level spectral imaging and analysis to reveal the organelle interactome
Alex M. Valm,Sarah Cohen,Wesley R. Legant,Justin Melunis,Uri Hershberg,Eric Wait,Andrew R. Cohen,Michael W. Davidson,Eric Betzig,Jennifer Lippincott-Schwartz +9 more
TL;DR: It is demonstrated that each organelle has a characteristic distribution and dispersion pattern in three-dimensional space and that there is a reproducible pattern of contacts among the six organelles, that is affected by microtubule and cell nutrient status.
Journal ArticleDOI
Membrane scission by the ESCRT-III complex
TL;DR: Three subunits of ESCRT-III, Vps20, Snf7 and Vps24, are sufficient to detach intralumenal vesicles and are reconstituted and visualized by fluorescence microscopy.
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Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales.
Yuting Guo,Di Li,Siwei Zhang,Yanrui Yang,Jia-Jia Liu,Xinyu Wang,Chong Liu,Daniel E. Milkie,Regan P Moore,U. Serdar Tulu,Daniel P. Kiehart,Junjie Hu,Jennifer Lippincott-Schwartz,Eric Betzig,Dong Li,Dong Li +15 more
TL;DR: Grazing incidence structured illumination microscopy (GI-SIM) was developed that is capable of imaging dynamic events near the basal cell cortex at 97-nm resolution and 266 frames/s over thousands of time points, and uncovered new ER remodeling mechanisms, such as hitchhiking of the ER on motile organelles.
Journal ArticleDOI
Cell volume change through water efflux impacts cell stiffness and stem cell fate.
Ming Guo,Adrian F. Pegoraro,Angelo S. Mao,Enhua H. Zhou,Praveen R. Arany,Yu Long Han,Yu Long Han,Dylan T. Burnette,Mikkel H. Jensen,Mikkel H. Jensen,Karen E. Kasza,Karen E. Kasza,Jeffrey R. Moore,Fred C. MacKintosh,Fred C. MacKintosh,Jeffrey J. Fredberg,David J. Mooney,Jennifer Lippincott-Schwartz,David A. Weitz +18 more
TL;DR: A robust and unified relationship between cell stiffness and cell volume is identified and it is found that changes in cell volume, and hence stiffness, alter stem-cell differentiation, regardless of the method by which these are induced.
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Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity
Maria S. Ioannou,Jesse Jackson,Shu-Hsien Sheu,Chi-Lun Chang,Aubrey V. Weigel,Hui Liu,H. Amalia Pasolli,C. Shan Xu,Song Pang,Doreen Matthies,Harald F. Hess,Jennifer Lippincott-Schwartz,Zhe Liu +12 more
TL;DR: These findings reveal that FA metabolism is coupled in neurons and astrocytes to protect neurons from FA toxicity during periods of enhanced activity, which could underlie both homeostasis and a variety of disease states of the brain.