Author
Jennifer N. Cambre
Bio: Jennifer N. Cambre is an academic researcher from Southern Methodist University. The author has contributed to research in topics: Copolymer & Boronic acid. The author has an hindex of 8, co-authored 9 publications receiving 2070 citations.
Topics: Copolymer, Boronic acid, Chain transfer, Polymerization, Pinacol
Papers
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TL;DR: It is the goal to emphasize underutilized adaptive behaviors of stimuli-responsive polymers so that novel applications and new generations of smart materials can be realized.
1,262 citations
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TL;DR: Boron-containing organic compounds have found widespread use in synthetic organic chemistry and have proven valuable in a variety of biomedical applications, including the treatment of HIV, obesity, diabetes, and cancer as mentioned in this paper.
361 citations
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TL;DR: Boronic acid-containing block copolymers capable of solution self-assembly into micells and reverse micelles in response to changes in temperature, pH, and sugar concentration were prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization.
239 citations
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TL;DR: Novel sugar-responsive block copolymers were prepared by RAFT blockCopolymerization of unprotected boronic acid monomers, providing a direct route to supramolecular assemblies that dissociate upon the addition of glucose.
184 citations
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TL;DR: The pinacol ester derivatized (co)polymers were easily deprotected by a mild and convenient strategy to yield free boronic acid polymers.
Abstract: A facile route to well-defined boronic acid (co)polymers from stable and easily manipulated boronic ester monomers is presented. The polymerization of 4-pinacolatoborylstyrene by reversible addition−fragmentation chain transfer (RAFT) yielded polymeric boronic acid precursors. Selection of stoichiometry allowed tuning of polymerization kinetics and targeting specific molecular weights in the range of Mn = 17000−32000 g/mol. The resulting low polydispersity poly(4-pinacolatoborylstyrene) homopolymers were employed as macro-chain transfer agents for block copolymerization with N,N-dimethylacrylamide to yield amphiphilic block copolymers that formed micelles in aqueous media. The pinacol ester derivatized (co)polymers were easily deprotected by a mild and convenient strategy to yield free boronic acid polymers
147 citations
Cited by
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TL;DR: This review will provide a comprehensive overview of general properties of alginate and its hydrogels, their biomedical applications, and suggest new perspectives for future studies with these polymers.
5,372 citations
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TL;DR: A review of the literature concerning classification of hydrogels on different bases, physical and chemical characteristics of these products, and technical feasibility of their utilization is presented in this paper, together with technologies adopted for hydrogel production together with process design implications, block diagrams, and optimized conditions of the preparation process.
3,529 citations
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TL;DR: Delivery of conventional chemotherapeutic anti-cancer drugs is mainly discussed and exploitation and the understanding of these characteristics to design new drug delivery systems targeting the tumor are focused on.
2,272 citations
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TL;DR: It is anticipated that precisely engineered nanoparticles will emerge as the next-generation platform for cancer therapy and many other biomedical applications.
Abstract: In medicine, nanotechnology has sparked a rapidly growing interest as it promises to solve a number of issues associated with conventional therapeutic agents, including their poor water solubility (at least, for most anticancer drugs), lack of targeting capability, nonspecific distribution, systemic toxicity, and low therapeutic index. Over the past several decades, remarkable progress has been made in the development and application of engineered nanoparticles to treat cancer more effectively. For example, therapeutic agents have been integrated with nanoparticles engineered with optimal sizes, shapes, and surface properties to increase their solubility, prolong their circulation half-life, improve their biodistribution, and reduce their immunogenicity. Nanoparticles and their payloads have also been favorably delivered into tumors by taking advantage of the pathophysiological conditions, such as the enhanced permeability and retention effect, and the spatial variations in the pH value. Additionally, targeting ligands (e.g., small organic molecules, peptides, antibodies, and nucleic acids) have been added to the surface of nanoparticles to specifically target cancerous cells through selective binding to the receptors overexpressed on their surface. Furthermore, it has been demonstrated that multiple types of therapeutic drugs and/or diagnostic agents (e.g., contrast agents) could be delivered through the same carrier to enable combination therapy with a potential to overcome multidrug resistance, and real-time readout on the treatment efficacy. It is anticipated that precisely engineered nanoparticles will emerge as the next-generation platform for cancer therapy and many other biomedical applications.
1,603 citations
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TL;DR: It is the goal to emphasize underutilized adaptive behaviors of stimuli-responsive polymers so that novel applications and new generations of smart materials can be realized.
1,262 citations