Jenny Dao

TL;DR: The output of type II secretion is greater in magnitude than previously appreciated and includes previously undescribed proteins, and data indicate that an enzyme with chitinase activity can promote infection of a mammalian host.

TL;DR: It is found that the role of LpnE in host cell invasion is dependent on the eight SLR regions of the protein, and the importance of theSLR regions to L. pneumophila virulence is defined.

TL;DR: The relative abilities of lapA and lapB mutants to infect human U937 cell macrophages as well as Hartmannella vermiformis and Acanthamoeba castellanii amoebae were examined, revealing an L. pneumophila gene that shows differential importance among protozoan infection models, suggesting that the legionellae might have evolved some of its factors to especially target certain of their protozoa hosts.

TL;DR: The impact of T2S on lung infection is a combination of at least three factors: the promotion of growth in macrophages, the facilitation ofrowth in epithelia, and the dampening of the chemokine and cytokine output from infected host cells.

TL;DR: There was a correlation between low-temperature survival and secretion function when 12 additional Legionella species were examined, and wild-type supernatants stimulated the growth of these mutants, indicating that secreted factors promote low-Temperature survival.