Jenny Nt Fung

TL;DR: This Seminar summarises current concepts about the origin of the disease, what predisposes patients to develop the disorder, and why all cases of ALS are not the same.

TL;DR: In this paper , SARS-CoV-2 infection of transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) as a COVID-19 pre-clinical model, established the presence of virus in the brain together with microglial activation and NLRP3 upregulation in comparison to uninfected mice.

TL;DR: It is demonstrated that glucose homeostasis and uptake are altered in SOD1G93A mice, which is linked to an increase in insulin-independent glucose uptake and a disturbance in glucagon sensitivity, suggesting glucagon secretion and signalling could be potential therapeutic targets for ALS.

TL;DR: In this paper , a genome-wide association study meta-analysis, including 60,674 cases and 701,926 controls of European and East Asian descent, identified 42 genomewide significant loci comprising 49 distinct association signals, which explained up to 5.01% of disease variance and regulated expression or methylation of genes in endometrium and blood.

TL;DR: Evidence of roles for activated microglia, astrocytes, and peripheral immune cells in HD is explored, possible biomarkers of neuroinflammation are explored, and neuroinflammatory biofluid and imaging biomarkers are explored.