Jeong Seok Lee

TL;DR: It is proposed that the type I IFN response plays a pivotal role in exacerbating inflammation in severe COVID-19.

TL;DR: Advances in control of fed-batch fermentations are reviewed: simple exponential feeding and inferential methods are examined, as are newer methods based on fuzzy control and neural networks that hold promise for optimizing feeds for complex fermentation systems.

TL;DR: Lee et al. as discussed by the authors showed that a robust type I interferon response could exacerbate hyperinflammation in the progression to severe COVID-19 through diverse mechanisms, and further understanding of the roles of type I Interferon at different stages of infection and in patients with mild versus severe CoV-19 will provide insights for the therapeutic use of interferron administration or JAK inhibitors.

TL;DR: In this article, a new method for PID controller tuning based on process models for integrating and unstable processes with time delay is proposed, which gives better closed-loop performance than the existing methods.

TL;DR: Cytokine secretion assays combined with MHC class I multimer staining revealed that the proportion of interferon-γ (IFN-γ)-producing cells was significantly lower among SARS-CoV-2-specific CD8+ T cells than those specific to influenza A virus.