J
Jeongwu Lee
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 69
Citations - 10341
Jeongwu Lee is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Stem cell & Glioma. The author has an hindex of 40, co-authored 66 publications receiving 9178 citations. Previous affiliations of Jeongwu Lee include Case Western Reserve University & Cleveland Clinic.
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Journal ArticleDOI
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.
Jeongwu Lee,Svetlana Kotliarova,Yuri Kotliarov,Aiguo Li,Qin Su,Nicholas M. Donin,Sandra Pastorino,Benjamin Purow,Neil Christopher,Wei Zhang,John K. Park,Howard A. Fine +11 more
TL;DR: Significant phenotypic and genotypic differences are demonstrated between primary human tumor-derived TSCs and their matched glioma cell lines, suggesting that TSC's may be a more reliable model than many commonly utilized cancer cell lines for understanding the biology of primary human tumors.
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microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma
Benjamin Kefas,Jakub Godlewski,Laurey Comeau,Yunqing Li,Roger Abounader,Michael P. Hawkinson,Jeongwu Lee,Howard A. Fine,E. Antonio Chiocca,Sean E. Lawler,Benjamin Purow +10 more
TL;DR: This study establishes miR-7 as a regulator of major cancer pathways and suggests that it has therapeutic potential for glioblastoma.
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Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells
Eunhee Kim,Mi-Suk Kim,Dong Hun Woo,Yongjae Shin,Jihye Shin,Nakho Chang,Young-Taek Oh,Hong Sug Kim,Jingeun Rheey,Ichiro Nakano,Cheolju Lee,Kyeung Min Joo,Jeremy N. Rich,Do-Hyun Nam,Jeongwu Lee +14 more
TL;DR: It is shown that EZH2 binds to and methylates STAT3, leading to enhanced STAT3 activity by increased tyrosine phosphorylation of STAT3.
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SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma
TL;DR: It is demonstrated that stage-specific embryonic antigen 1(SSEA-1/LeX)+ GBM cells fulfill the functional criteria for TSC/TIC, since S SEA-1+ cells are highly tumorigenic in vivo, unlike SSEA- 1- cells.
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Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation.
Benjamin Purow,Raqeeb M. Haque,Martha Noel,Qin Su,Michael J. Burdick,Jeongwu Lee,Tilak K. Sundaresan,Sandra Pastorino,John K. Park,Irina Mikolaenko,Dragan Maric,Charles G. Eberhart,Howard A. Fine +12 more
TL;DR: These results show, for the first time, the dependence of cancer cells on a single Notch ligand; they suggest a potential Notch juxtacrine/autocrine loop in gliomas and may present novel therapeutic targets in the treatment of glioma.