J
Jer-Yuarn Wu
Researcher at Academia Sinica
Publications - 216
Citations - 16230
Jer-Yuarn Wu is an academic researcher from Academia Sinica. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 49, co-authored 211 publications receiving 13835 citations. Previous affiliations of Jer-Yuarn Wu include China Medical University (Taiwan) & National Cheng Kung University.
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Journal ArticleDOI
Medical genetics: A marker for Stevens-Johnson syndrome
Wen-Hung Chung,Shuen-Iu Hung,Hong-Shang Hong,Mo-Song Hsih,Li-Cheng Yang,Hsin-Chun Ho,Jer-Yuarn Wu,Jer-Yuarn Wu,Yuan-Tsong Chen,Yuan-Tsong Chen +9 more
TL;DR: This paper showed that there is a strong association in Han Chinese between the human leukocyte antigen HLA-B*1502 and Stevens-Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures.
Journal ArticleDOI
HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
Shuen Lu Hung,Wen-Hung Chung,Wen-Hung Chung,Wen-Hung Chung,Lieh Bang Liou,Chen Chung Chu,Marie Lin,Hsien Ping Huang,Yen Ling Lin,Joung Liang Lan,Li Cheng Yang,Hong Shang Hong,Ming Jing Chen,Ping Chin Lai,Mai Szu Wu,Chia-Yu Chu,Chia-Yu Chu,Kuo Hsien Wang,Chien-Hsiun Chen,Cathy S.J. Fann,Jer-Yuarn Wu,Jer-Yuarn Wu,Yuan-Tsong Chen,Yuan-Tsong Chen +23 more
TL;DR: The results indicated that allopurinol-SCAR is strongly associated with a genetic predisposition in Han Chinese, and in particular, HLA-B*5801 allele is an important genetic risk factor for this life-threatening condition.
Journal ArticleDOI
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Anubha Mahajan,Min Jin Go,Weihua Zhang,Jennifer E. Below,Kyle J. Gaulton,Teresa Ferreira,Momoko Horikoshi,Andrew D. Johnson,Maggie C.Y. Ng,Inga Prokopenko,Inga Prokopenko,Danish Saleheen,Xu Wang,Eleftheria Zeggini,Gonçalo R. Abecasis,Linda S. Adair,Peter Almgren,Mustafa Atalay,Tin Aung,Tin Aung,Damiano Baldassarre,Beverley Balkau,Beverley Balkau,Yuqian Bao,Anthony H. Barnett,Anthony H. Barnett,Inês Barroso,Inês Barroso,Inês Barroso,Abdul Basit,Latonya F. Been,John Beilby,John Beilby,Graeme I. Bell,Rafn Benediktsson,Richard N. Bergman,Bernhard OBoehm,Bernhard OBoehm,Eric Boerwinkle,Eric Boerwinkle,Lori L. Bonnycastle,Noël P. Burtt,Qiuyin Cai,Harry Campbell,Jason Carey,Stéphane Cauchi,Mark J. Caulfield,Juliana C.N. Chan,Li Ching Chang,Tien-Jyun Chang,Yi-Cheng Chang,Guillaume Charpentier,Chien-Hsiun Chen,Chien-Hsiun Chen,Han Chen,Yuan-Tsong Chen,Kee Seng Chia,Manickam Chidambaram,Peter S. Chines,Nam H. Cho,Young Min Cho,Lee-Ming Chuang,Francis S. Collins,Marilyn C. Cornelis,David Couper,Andrew Crenshaw,Rob M. van Dam,Rob M. van Dam,John Danesh,Debashish Das,Ulf de Faire,George Dedoussis,Panos Deloukas,Antigone S. Dimas,Christian Dina,Christian Dina,Alex S. F. Doney,Peter Donnelly,Mozhgan Dorkhan,Cornelia M. van Duijn,Josée Dupuis,Josée Dupuis,Sarah Edkins,Paul Elliott,Paul Elliott,Valur Emilsson,Raimund Erbel,Johan G. Eriksson,Jorge Escobedo,Tõnu Esko,Tõnu Esko,Elodie Eury,Jose C. Florez,Jose C. Florez,Pierre Fontanillas,Nita G. Forouhi,Tom Forsén,Caroline S. Fox,Caroline S. Fox,Ross M. Fraser,Timothy M. Frayling,Philippe Froguel,Philippe Froguel,Philippe M. Frossard,Yu-Tang Gao,Karl Gertow,Christian Gieger,Bruna Gigante,Harald Grallert,George B. Grant,Leif Groop,Christopher J. Groves,Elin Grundberg,Elin Grundberg,Elin Grundberg,Candace Guiducci,Anders Hamsten,Bok Ghee Han,Hara Kazuo,Neelam Hassanali,Andrew T. Hattersley,Caroline Hayward,Åsa K. Hedman,Christian Herder,Albert Hofman,Oddgeir L. Holmen,Kees Hovingh,Astradur B. Hreidarsson,Cheng Hu,Frank B. Hu,Jennie Hui,Jennie Hui,Steve E. Humphries,Sarah E. Hunt,David J. Hunter,Kristian Hveem,Zafar I. Hydrie,Hiroshi Ikegami,Thomas Illig,Erik Ingelsson,Erik Ingelsson,Muhammed Islam,Bo Isomaa,Anne U. Jackson,Tazeen H. Jafar,Alan James,Alan James,Weiping Jia,Karl-Heinz Jöckel,Anna Jonsson,Jeremy B M Jowett,Takashi Kadowaki,Hyun Min Kang,Stavroula Kanoni,Wen Hong L. Kao,Sekar Kathiresan,Sekar Kathiresan,Norihiro Kato,Prasad Katulanda,Prasad Katulanda,Sirkka Keinänen-Kiukaanniemi,Ann M. Kelly,Ann M. Kelly,Hassan Khan,Kay-Tee Khaw,Chiea Chuen Khor,Chiea Chuen Khor,Chiea Chuen Khor,Hyung Lae Kim,Sangsoo Kim,Young Jin Kim,Leena Kinnunen,Norman Klopp,Augustine Kong,Eeva Korpi-Hyövälti,Sudhir Kowlessur,Peter Kraft,Jasmina Kravic,Malene M. Kristensen,S. Krithika,Ashok Kumar,Jesús Kumate,Johanna Kuusisto,Soo Heon Kwak,Markku Laakso,Vasiliki Lagou,Timo A. Lakka,Claudia Langenberg,Cordelia Langford,Robert W. Lawrence,Karin Leander,Jen Mai Lee,Nanette R. Lee,Man Li,Xinzhong Li,Yun Li,Junbin Liang,Samuel Liju,Wei-Yen Lim,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Eero Lindholm,Ching-Ti Liu,Jianjun Liu,Stéphane Lobbens,Jirong Long,Ruth J. F. Loos,Ruth J. F. Loos,Wei Lu,Jian'an Luan,Valeriya Lyssenko,Ronald C. WMa,Shiro Maeda,Reedik Mägi,Satu Männistö,David R. Matthews,James B. Meigs,James B. Meigs,Olle Melander,Andres Metspalu,Julia Meyer,Ghazala Mirza,Evelin Mihailov,Susanne Moebus,Viswanathan Mohan,Viswanathan Mohan,Karen L. Mohlke,Andrew D. Morris,Thomas WMühleisen,Martina Müller-Nurasyid,Martina Müller-Nurasyid,Bill Musk,Bill Musk,Jiro Nakamura,Eitaro Nakashima,Pau Navarro,Peng Keat Ng,Alexandra C. Nica,Peter M. Nilsson,Inger Njølstad,Markus M. Nöthen,Keizo Ohnaka,Twee Hee Ong,Katharine R. Owen,Colin N. A. Palmer,James S. Pankow,Kyong Soo Park,Melissa Parkin,Sonali Pechlivanis,Nancy L. Pedersen,Leena Peltonen,John R. B. Perry,John R. B. Perry,Annette Peters,Janani Pinidiyapathirage,Carl G. P. Platou,Simon C. Potter,Jackie F. Price,Lu Qi,Venkatesan Radha,Loukianos S. Rallidis,Asif Rasheed,Wolfgang Rathmann,Rainer Rauramaa,Soumya Raychaudhuri,N. William Rayner,Simon D. Rees,Simon D. Rees,Emil Rehnberg,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Neil Robertson,Michael Roden,Elizabeth J. Rossin,Elizabeth J. Rossin,Elizabeth J. Rossin,Igor Rudan,Denis Rybin,Timo Saaristo,Veikko Salomaa,Juha Saltevo,Maria Samuel,Dharambir KSanghera,Jouko Saramies,James Scott,Laura J. Scott,Robert A. Scott,Ayellet V. Segrè,Ayellet V. Segrè,Joban Sehmi,Joban Sehmi,Bengt Sennblad,Nabi Shah,Sonia Shah,A. Samad Shera,Xiao-Ou Shu,Alan R. Shuldiner,Gunnar Sigurosson,Eric J.G. Sijbrands,Angela Silveira,Xueling Sim,Xueling Sim,Suthesh Sivapalaratnam,Kerrin S. Small,Kerrin S. Small,Wing-Yee So,Alena Stančáková,Kari Stefansson,Kari Stefansson,Gerald Steinbach,Valgerdur Steinthorsdottir,Kathleen Stirrups,Rona J. Strawbridge,Heather M. Stringham,Qi Sun,Chen Suo,Ann-Christine Syvänen,Ryoichi Takayanagi,Fumihiko Takeuchi,Wan Ting Tay,Tanya M. Teslovich,Barbara Thorand,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Emmi Tikkanen,Emmi Tikkanen,Joseph Trakalo,Elena Tremoli,Mieke D. Trip,Fuu Jen Tsai,Tiinamaija Tuomi,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,André G. Uitterlinden,Adan Valladares-Salgado,Sailaja Vedantam,Sailaja Vedantam,Fabrizio Veglia,Benjamin F. Voight,Benjamin F. Voight,Congrong Wang,Nicholas J. Wareham,Roman Wennauer,Ananda R. Wickremasinghe,Tom Wilsgaard,James F. Wilson,S Wiltshire,Wendy Winckler,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Andrew R. Wood,Jer-Yuarn Wu,Jer-Yuarn Wu,Ying Wu,Ken Yamamoto,Toshimasa Yamauchi,Mingyu Yang,Loic Yengo,Mitsuhiro Yokota,Robin Young,Delilah Zabaneh,Fan Zhang,Rong Zhang,Wei Zheng,Paul Zimmet,David Altshuler,David Altshuler,Donald W. Bowden,Donald W. Bowden,Yoon Shin Cho,Nancy J. Cox,Miguel Cruz,Craig L. Hanis,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Jong-Young Lee,Mark Seielstad,Mark Seielstad,Mark Seielstad,Yik Ying Teo,Yik Ying Teo,Michael Boehnke,Esteban J. Parra,John C. Chambers,John C. Chambers,John C. Chambers,E. Shyong Tai,Mark I. McCarthy,Andrew P. Morris,Andrew P. Morris +395 more
TL;DR: In this paper, the authors aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry.
Journal ArticleDOI
Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis
Wen-Hung Chung,Wen-Hung Chung,Shuen-Iu Hung,Shuen-Iu Hung,Jui-Yung Yang,Shih-Chi Su,Shien-Ping Huang,Chun-Yu Wei,See-Wen Chin,Chien-Chun Chiou,Sung-Chao Chu,Hsin-Chun Ho,Chih-Hsun Yang,Chi-Fang Lu,Jer-Yuarn Wu,You-Di Liao,Yuan-Tsong Chen,Yuan-Tsong Chen +17 more
TL;DR: It is demonstrated that secretory granulysin is a key molecule responsible for the disseminated keratinocyte death in SJS-TEN and this work highlights a mechanism for CTL- or NK cell—mediated cytotoxicity that does not require direct cellular contact.
Journal ArticleDOI
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
Yoon Shin Cho,Chien Hsiun Chen,Chien Hsiun Chen,Cheng Hu,Jirong Long,Rick Twee-Hee Ong,Xueling Sim,Fumihiko Takeuchi,Ying Wu,Min Jin Go,Toshimasa Yamauchi,Yi-Cheng Chang,Soo Heon Kwak,Ronald C.W. Ma,Ken Yamamoto,Linda S. Adair,Tin Aung,Qiuyin Cai,Li Ching Chang,Yuan-Tsong Chen,Yu-Tang Gao,Frank B. Hu,Hyung Lae Kim,Sangsoo Kim,Young-Jin Kim,Jeannette Lee,Nanette R. Lee,Yun Li,Jianjun Liu,Wei Lu,Jiro Nakamura,Eitaro Nakashima,Daniel P.K. Ng,Wan Ting Tay,Fuu Jen Tsai,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Mitsuhiro Yokota,Wei Zheng,Rong Zhang,Congrong Wang,Wing-Yee So,Keizo Ohnaka,Hiroshi Ikegami,Hara Kazuo,Young Min Cho,Nam H. Cho,Tien-Jyun Chang,Yuqian Bao,Åsa K. Hedman,Andrew P. Morris,Mark I. McCarthy,Ryoichi Takayanagi,Kyong Soo Park,Weiping Jia,Lee-Ming Chuang,Juliana C.N. Chan,Shiro Maeda,Takashi Kadowaki,Jong-Young Lee,Jer-Yuarn Wu,Jer-Yuarn Wu,Yik Ying Teo,Yik Ying Teo,E. Shyong Tai,Xiao-Ou Shu,Karen L. Mohlke,Norihiro Kato,Bok Ghee Han,Mark Seielstad,Mark Seielstad,Mark Seielstad +72 more
TL;DR: The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3, which may regulate glucose-dependent insulin secretion in the pancreas.