Jeremy M. Simon

TL;DR: The Encyclopedia of DNA Elements project provides new insights into the organization and regulation of the authors' genes and genome, and is an expansive resource of functional annotations for biomedical research.

TL;DR: The first extensive map of human DHSs identified through genome-wide profiling in 125 diverse cell and tissue types is presented, revealing novel relationships between chromatin accessibility, transcription, DNA methylation and regulatory factor occupancy patterns.

TL;DR: It is found that human islet samples heterozygous for rs7903146 showed allelic imbalance in islet FAIRE signals and that the variant alters enhancer activity, indicating that genetic variation at this locus acts in cis with local chromatin and regulatory changes.

TL;DR: Gene expression and RNA Pol II binding data support the hypothesis that COREs control gene activity required for the maintenance of cell-type identity, and it is shown that open chromatin regions bound by CTCF are potent insulators.

TL;DR: FAIRE (formaldehyde-assisted isolation of regulatory elements) has low technical variability, which allows its usage in large-scale studies of chromatin from normal or diseased tissues, and the entire procedure can be completed in 3 d.