J
Jérôme Alexandre
Researcher at University of Paris
Publications - 231
Citations - 11148
Jérôme Alexandre is an academic researcher from University of Paris. The author has contributed to research in topics: Cancer & Nivolumab. The author has an hindex of 39, co-authored 230 publications receiving 9289 citations. Previous affiliations of Jérôme Alexandre include University of Texas MD Anderson Cancer Center & Southern General Hospital.
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Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
Safety and Pharmacokinetics of Escalated Doses of Weekly Intravenous Infusion of CCI-779, a Novel mTOR Inhibitor, in Patients With Cancer
Eric Raymond,Jérôme Alexandre,Sandrine Faivre,Karina Vera,Eric Materman,Joseph Boni,Cathie Leister,Joan M. Korth-Bradley,Axel Hanauske,Jean-Pierre Armand +9 more
TL;DR: CCI-779 displayed no immunosuppressive effects with manageable and reversible adverse events at doses up to 220 mg/m(2), the highest dose tested and not based on classical definitions of maximum-tolerated dose is being tested in phase II trials in patients with breast and renal cancer.
Journal Article
Controlling Tumor Growth by Modulating Endogenous Production of Reactive Oxygen Species
Alexis Laurent,Carole Nicco,Christiane Chéreau,Claire Goulvestre,Jérôme Alexandre,Arnaud Alves,Eva Lévy,François Goldwasser,Yves Panis,Olivier Soubrane,Bernard Weill,Frédéric Batteux +11 more
TL;DR: In conclusion, antioxidant molecules may have opposite effects on tumor growth as SOD mimics can act in synergy with cytotoxic drugs to treat colon and liver cancers and reactive oxygen species can promote normal cellular proliferation and carcinogenesis.
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Novel Action of Paclitaxel against Cancer Cells: Bystander Effect Mediated by Reactive Oxygen Species
TL;DR: This study revealed a novel mechanism by which paclitaxel induces toxic bystander effect through generation of extracellular H(2)O( 2) from the membrane-associated NOX, which may contribute to the potent anticancer activity of pac litaxel and provide a novel basis to improve the clinical use of this important drug.
Journal ArticleDOI
Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo.
Jérôme Alexandre,Frédéric Batteux,Carole Nicco,Christiane Chéreau,Alexis Laurent,Loïc Guillevin,Bernard Weill,François Goldwasser +7 more
TL;DR: The accumulation of H2O2 is an early and crucial step for paclitaxel‐induced cancer cell death before the commitment of the cells into apoptosis, suggesting that ROS participate in vitro and in vivo to pac litaxel cytotoxicity.