J
Jerome P.L. Ng
Researcher at Macau University of Science and Technology
Publications - 10
Citations - 92
Jerome P.L. Ng is an academic researcher from Macau University of Science and Technology. The author has contributed to research in topics: Chemistry & Docking (molecular). The author has an hindex of 2, co-authored 10 publications receiving 16 citations.
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Corilagin prevents SARS-CoV-2 infection by targeting RBD-ACE2 binding.
Li Jun Yang,Rui Hong Chen,Sami Hamdoun,Paolo Coghi,Jerome P.L. Ng,David Wei Zhang,Xiaoling Guo,Chenglai Xia,Betty Yuen Kwan Law,Vincent Kam Wai Wong +9 more
TL;DR: Wang et al. as mentioned in this paper characterized an active compound, corilagin derived from Phyllanthus urinaria as potential SARS-CoV-2 entry inhibitors for its possible preventive application in daily anti-virus hygienic products.
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Computational and experimental insights on the interaction of artemisinin, dihydroartemisinin and chloroquine with SARS-CoV-2 spike protein receptor-binding domain (RBD).
Giovanni Ribaudo,Paolo Coghi,Li Jun Yang,Jerome P.L. Ng,Andrea Mastinu,Maurizio Memo,Vincent Kam Wai Wong,Alessandra Gianoncelli +7 more
TL;DR: In this paper, the interaction of artemisinin, its metabolites and chloroquine with the receptor-binding domain (RBD) was investigated using computational tools and in-vitro simulations.
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Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota
Wu Zeng,An Guo Wu,Xiao-Gang Zhou,Imran Khan,Rui Long Zhang,Hang Hong Lo,Li Qun Qu,Lin Lin Song,Xiao Yun Yun,Hui Miao Wang,Juan Chen,Jerome P.L. Ng,Fang Ren,Si Yu Yuan,Lu Yu,Yong Tang,Guo Xin Huang,Vincent Kam Wai Wong,Sookja Kim Chung,Simon Wing Fai Mok,Da Lian Qin,Hua Lin Sun,Liang Liu,W.L. Wendy Hsiao,Betty Yuen Kwan Law +24 more
TL;DR: In this paper, an active methanol fraction of Radix polygalae (RP) containing 17 RP saponins (RPS) was identified, which can modulate the aging process, gut microbiota diversity and rectify several aging-related phenotypes.
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A Drug Repurposing Approach for Antimalarials Interfering with SARS-CoV-2 Spike Protein Receptor Binding Domain (RBD) and Human Angiotensin-Converting Enzyme 2 (ACE2).
Paolo Coghi,Li Jun Yang,Jerome P.L. Ng,Richard K. Haynes,Maurizio Memo,Alessandra Gianoncelli,Vincent Kam Wai Wong,Giovanni Ribaudo +7 more
TL;DR: In this article, computational and experimental techniques were combined to screen antimalarial compounds from different chemical classes, with the aim of identifying small molecules interfering with the RBD-ACE2 interaction and, consequently, with cell invasion.
Journal ArticleDOI
Synthesis, computational docking and biological evaluation of celastrol derivatives as dual inhibitors of SERCA and P-glycoprotein in cancer therapy.
Paolo Coghi,Jerome P.L. Ng,Onat Kadioglu,Betty Yuen Kwan Law,Alena Congling Qiu,Mohamed E.M. Saeed,Xi Chen,Chi Kio Ip,Thomas Efferth,Liang Liu,Vincent Kam Wai Wong +10 more
TL;DR: A series of eleven dipeptide celastrol derivatives were designed, synthesized, and evaluated for their in vitro cytotoxic activities against six human cancer cell lines (A549, HepG2, HepAD38, PC3, DLD-1 Bax-Bak WT and DKO) and three human normal cells (LO2, BEAS-2B, CCD19Lu) as mentioned in this paper.