J
Jérôme Pugin
Researcher at University of Geneva
Publications - 222
Citations - 17166
Jérôme Pugin is an academic researcher from University of Geneva. The author has contributed to research in topics: Intensive care & Medicine. The author has an hindex of 54, co-authored 193 publications receiving 15641 citations. Previous affiliations of Jérôme Pugin include Geneva College & Innogenetics.
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Journal ArticleDOI
Diagnosis of Ventilator-associated Pneumonia by Bacteriologic Analysis of Bronchoscopic and Nonbronchoscopic “Blind” Bronchoalveolar Lavage Fluid
TL;DR: A good correlation between clinical score and quantitative bacteriology was observed and patients with pulmonary infection could be distinguished by a BI greater than or equal to 5 with a sensitivity of 93% and a specificity of 100% (B-BAL).
Journal ArticleDOI
Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis
Stéphan Juergen Harbarth,Katarina Holeckova,Céline Froidevaux,Didier Pittet,Bara Ricou,Georges E. Grau,Laszlo Vadas,Jérôme Pugin +7 more
TL;DR: Elevated PCT concentrations appear to be a promising indicator of sepsis in newly admitted, critically ill patients capable of complementing clinical signs and routine laboratory parameters suggestive of severe infection.
Journal ArticleDOI
Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14.
Jérôme Pugin,Cornelia-C. Schurer-Maly,Didier J. Leturcq,Ann Moriarty,Richard J. Ulevitch,Peter S. Tobias +5 more
TL;DR: It is shown that soluble CD14 (sCD14) is required for activation of endothelial and epithelial cells by LPS, and it is proposed that LPS-LBP complexes transfer LPS to sCD14, and the L PS-s CD14 complexes then bind to a cellular receptor.
Journal ArticleDOI
Protection from septic shock by neutralization of macrophage migration inhibitory factor.
Thierry Calandra,Bernd Echtenacher,Didier Le Roy,Jérôme Pugin,Christine N. Metz,Lothar Hültner,Didier Heumann,Daniela N. Männel,Richard Bucala,Michel P. Glauser +9 more
TL;DR: It is reported here that macrophage migration inhibitory factor (MIF) is a critical mediator of septic shock and a new target for therapeutic intervention is identified.
Journal ArticleDOI
CD14 is a pattern recognition receptor.
Jérôme Pugin,I D Heumann,Alexander Tomasz,Vladimir V. Kravchenko,Y Akamatsu,M Nishijima,M. P. Glauser,Peter S. Tobias,Richard J. Ulevitch +8 more
TL;DR: It is proposed that CD14 is a receptor used by mammalian cells to recognize and signal responses to a diverse array of bacterial constituents, which defines the molecular basis for innate microbial immunity.