Jesper Lagergren

TL;DR: There is a strong and probably causal relation between gastroesophageal reflux and esophageaal adenocarcinoma, and the relation between reflux And gastric cardia is relatively weak.

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: These guidelines provide a practical and evidence-based resource for the management of patients with Barrett's oesophagus and related early neoplasia and suggested stratification of patients according to their estimated cancer risk based on clinical and histopathological criteria for the first time.

TL;DR: The primary aim was to precisely estimate the strength of the association while adjusting for potential confounding factors, and the effects of body mass early in life compared with its effects late in life and assessed the relative importance of physical activity and energy intake.

TL;DR: There is a significant association between body mass and symptoms of gastroesophageal reflux, especially among women, especially premenopausally, and use of hormone therapy strengthens the association, suggesting that estrogens may play an important role in the etiology of reflux disease.