J
Jesper Wengel
Researcher at University of Southern Denmark
Publications - 526
Citations - 21327
Jesper Wengel is an academic researcher from University of Southern Denmark. The author has contributed to research in topics: Oligonucleotide & Locked nucleic acid. The author has an hindex of 61, co-authored 521 publications receiving 20013 citations. Previous affiliations of Jesper Wengel include Institut de Chimie des Substances Naturelles & Max Planck Society.
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Journal ArticleDOI
LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition
Alexei A. Koshkin,Sanjay K. Singh,Poul Nielsen,Vivek K. Rajwanshi,Ravindra Kumar,Michael Meldgaard,Carl Erik Olsen,Jesper Wengel +7 more
TL;DR: Studies of mis-matched sequences show that LNA obey the Watson-Crick base pairing rules with generally improved selectivities compared to the corresponding unmodified reference strands.
Journal ArticleDOI
Phytochemistry of the genus Piper
Virinder S. Parmar,Subhash C. Jain,Kirpal S. Bisht,Rajni Jain,Poonam Taneja,Amitabh Jha,O. D. Tyagi,Ashok K. Prasad,Jesper Wengel,Carl Erik Olsen,Per M. Boll,Per M. Boll +11 more
TL;DR: The secondary metabolites isolated from Piper species for the period 1907 to June 1996 have been reviewed in this paper, where nearly six hundred chemical constituents belonging to different classes of bioactive compounds are listed together with their source(s) and references.
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LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition
TL;DR: A novel class of nucleic acid analogues, termed LNA (locked nucleic acids), is introduced following the Watson–Crick base pairing rules, which forms duplexes with complementary DNA and RNA with remarkably increased thermal stabilities and generally improved selectivities.
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Potent and nontoxic antisense oligonucleotides containing locked nucleic acids
Claes Wahlestedt,Peter Salmi,Liam Good,Johanna Kela,Thomas Johnsson,Tomas Hökfelt,Christian Broberger,Frank Porreca,Josephine Lai,Kunkun Ren,Michael H. Ossipov,Alexei A. Koshkin,Nana Jakobsen,Jan Skouv,Henrik Oerum,Mogens Havsteen Jacobsen,Jesper Wengel +16 more
TL;DR: It is demonstrated here that a high-affinity DNA analog, locked nucleic acid (LNA), confers several desired properties to antisense agents, and LNA/DNA copolymers exhibited potent antisense activity on assay systems as disparate as a G-protein-coupled receptor in living rat brain and an Escherichia coli reporter gene.
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LNA (Locked Nucleic Acid): High-Affinity Targeting of Complementary RNA and DNA†
Birte Vester,Jesper Wengel +1 more
TL;DR: The wide applicability of LNA oligonucleotides for gene silencing and their use for research and diagnostic purposes are documented in a number of recent reports, some of which are described herein.