J
Jesus G. Valenzuela
Researcher at National Institutes of Health
Publications - 234
Citations - 13151
Jesus G. Valenzuela is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Leishmania & Saliva. The author has an hindex of 64, co-authored 219 publications receiving 12001 citations. Previous affiliations of Jesus G. Valenzuela include Salk Institute for Biological Studies & Center for Biologics Evaluation and Research.
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Journal ArticleDOI
Development of a Natural Model of Cutaneous Leishmaniasis: Powerful Effects of Vector Saliva and Saliva Preexposure on the Long-Term Outcome of Leishmania major Infection in the Mouse Ear Dermis
Yasmine Belkaid,Shaden Kamhawi,Govind B. Modi,Jesus G. Valenzuela,Nancy Noben-Trauth,Edgar Rowton,José M. C. Ribeiro,David L. Sacks +7 more
TL;DR: The studies reveal a dramatic exacerbating effect of SGS on lesion development in the dermal site, and a complete abrogation of this effect in mice preexposed to salivary components, the first to suggest that for individuals at risk of vector-borne infections, history of exposure to vector saliva might influence the outcome of Exposure to transmitted parasites.
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Toward a Defined Anti-Leishmania Vaccine Targeting Vector Antigens: Characterization of a Protective Salivary Protein
Jesus G. Valenzuela,Yasmine Belkaid,Mark Garfield,Susana Mendez,Shaden Kamhawi,Edgar Rowton,David L. Sacks,José M. C. Ribeiro +7 more
TL;DR: Results indicate that DTH response against saliva provides most or all of the protective effects of this vaccine and that salivary gland proteins or their cDNAs are viable vaccine targets against leishmaniasis.
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An annotated catalog of salivary gland transcripts from Ixodes scapularis ticks.
José M. C. Ribeiro,Francisco J. Alarcon-Chaidez,Ivo M.B. Francischetti,Ben J. Mans,Thomas N. Mather,Jesus G. Valenzuela,Stephen K. Wikel +6 more
TL;DR: Over 8000 expressed sequence tags from six different salivary gland cDNA libraries from the tick Ixodes scapularis support the hypothesis that gene duplication, most possibly including genome duplications, is a major player in tick evolution.
Journal ArticleDOI
Exploring the sialome of the tick Ixodes scapularis
Jesus G. Valenzuela,Ivo M.B. Francischetti,Van My Pham,Mark Garfield,Thomas N. Mather,José M. C. Ribeiro +5 more
TL;DR: This work provides information into the diversity of messages expressed in the salivary glands of the tick Ixodes scapularis, describes novel sequences that may be responsible for known biological activites, indicates further biological activities that might be present in I. scAPularis saliva and identifies novel vaccine targets that may been used in Lyme disease prevention.
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Ixolaris, a novel recombinant tissue factor pathway inhibitor (TFPI) from the salivary gland of the tick, Ixodes scapularis: identification of factor X and factor Xa as scaffolds for the inhibition of factor VIIa/tissue factor complex.
Ivo M.B. Francischetti,Jesus G. Valenzuela,John F. Andersen,Thomas N. Mather,José M. C. Ribeiro +4 more
TL;DR: Recombinant Ixolaris was expressed in insect cells and shown to inhibit factor VIIa (FVIIa)/tissue factor (TF)-induced factor X (FX) activation with an inhibitory concentration of 50% in the picomolar range, implying that the Gla domain is necessary for FVIIa/TF/IxolarIS/FX(a) complex formation.