Ji-Hua Wang

Bio: Ji-Hua Wang is an academic researcher from Yunnan Normal University. The author has contributed to research in topics: Syzygium & Daucosterol. The author has an hindex of 5, co-authored 11 publications receiving 105 citations.

3,7-Dihydroxy-2,4,6-trimethoxyphenanthrene, A New Phenanthrene from Bulbophyllum Odoratissimum

Abstract: A new phenanthrene derivative 3,7-dihydroxy-2,4,6-trimethoxyphenanthrene was isolated from the all plant of Bulbophyllum odoratissimum, and its structure was elucidated by extensive spectral studies and chemical transformation. The compound displayed cytotoxicity against the growth of human leukemia cell lines K562 and HL-60, human lung adenocarcinoma A549, human hepatoma BEL-7402 and human stomach cancer cell lines SGC-7901 with IC 50 values of 14.23, 10.02, 3.42, 15.36 and 1.13 mg/ml respectively.

Isolation of 5-hydroxypyrrolidin-2-one and other constituents from the young fronds of Pteridium aquilinum.

Abstract: 5-Hydroxypyrrolidin-2-one, along with (2R)-pterosin B, shikimic acid, kaempferol-3-O-β-D-glucopyranoside, transtiliroside, β-sitosterol, daucosterol, glycerol 1-stearate and benzoic acid, were isolated from the young fronds of the bracken fern Pteridium aquilinum. 5-Hydroxypyrrolidin-2-one, shikimic acid and glycerol 1-stearate were isolated from the plant for the first time.

A new cyclopentanone derivative from Euphorbia hirta

Abstract: A new cyclopentanone derivative, (1'R,5'R)-5-(5'-carboxymethyl-2'-oxocyclopentyl)-3Z-pentenyl acetate (1), was isolated from Euphorbia hirta. Its structure was elucidated on the basis of spectroscopic analysis including 1D and 2D NMR techniques. The EtOAc extract of Euphorbia hirta was evaluated against K562 and A549 cancer cell lines.

A NEW TRITERPENOID ACID FROM Schisandra henryi

Abstract: A new lanostane triterpenoid acid, nigranoic acid 3-ethyl ester (1), together with two known lanostane triterpenoid acids, isoschizandronic acid (2) and anwuweizic acid (3), was isolated from the stems of Schisandra henryi Clarke. The new compound was identified based on extensive spectroscopic studies including HR-ESI-MS and 2D NMR spectra, and the known compounds were identified by their spectroscopic data analysis and comparison with reports in the literature. Compounds 2 and 3 were isolated from the plant for the first time.

A review on the dietary flavonoid kaempferol.

Abstract: Epidemiological studies have revealed that a diet rich in plant-derived foods has a protective effect on human health. Identifying bioactive dietary constituents is an active area of scientific investigation that may lead to new drug discovery. Kaempferol (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a flavonoid found in many edible plants (e.g. tea, broccoli, cabbage, kale, beans, endive, leek, tomato, strawberries and grapes) and in plants or botanical products commonly used in traditional medicine (e.g. Ginkgo biloba, Tilia spp, Equisetum spp, Moringa oleifera, Sophora japonica and propolis). Some epidemiological studies have found a positive association between the consumption of foods containing kaempferol and a reduced risk of developing several disorders such as cancer and cardiovascular diseases. Numerous preclinical studies have shown that kaempferol and some glycosides of kaempferol have a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective, neuroprotective, antidiabetic, anti-osteoporotic, estrogenic/antiestrogenic, anxiolytic, analgesic and antiallergic activities. In this article, the distribution of kaempferol in the plant kingdom and its pharmacological properties are reviewed. The pharmacokinetics (e.g. oral bioavailability, metabolism, plasma levels) and safety of kaempferol are also analyzed. This information may help understand the health benefits of kaempferol-containing plants and may contribute to develop this flavonoid as a possible agent for the prevention and treatment of some diseases.

Collection and trade of wild-harvested orchids in Nepal

Abstract: Background Wild orchids are illegally harvested and traded in Nepal for use in local traditional medicine, horticulture, and international trade. This study aims to: 1) identify the diversity of species of wild orchids in trade in Nepal; 2) study the chain of commercialization from collector to client and/or export; 3) map traditional knowledge and medicinal use of orchids; and 4) integrate the collected data to propose a more sustainable approach to orchid conservation in Nepal.

Gigantol, a bibenzyl from Dendrobium draconis, inhibits the migratory behavior of non-small cell lung cancer cells.

Abstract: Lung cancer is one of the most common causes of cancer death due to its high metastasis potential. The process of cancer migration is an early step that is required for successful metastasis. The discovery and development of natural compounds for cancer therapy have garnered increasing attention in recent years. Gigantol (1) is a bibenzyl compound derived from the Thai orchid, Dendrobium draconis. It exhibits significant cytotoxic activity against several cancer cell lines; however, until recently, the role of 1 on tumor metastasis has not been characterized. This study demonstrates that 1 suppresses the migratory behavior of non-small cell lung cancer H460 cells. Western blot analysis reveals that 1 down-regulates caveolin-1 (Cav-1), activates ATP-dependent tyrosine kinase (phosphorylated Akt at Ser 473), and cell division cycle 42 (Cdc42), thereby suppressing filopodia formation. The inhibitory effect of 1 on cell movement is also exhibited in another lung cancer cell line, H292, but not in normal human...