J
Jia-Yi Li
Researcher at Lund University
Publications - 142
Citations - 10686
Jia-Yi Li is an academic researcher from Lund University. The author has contributed to research in topics: Embryonic stem cell & Parkinson's disease. The author has an hindex of 45, co-authored 141 publications receiving 9385 citations. Previous affiliations of Jia-Yi Li include University of Nebraska Medical Center & China Medical University (PRC).
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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.
Jia-Yi Li,Elisabet Englund,Janice L. Holton,Denis Soulet,Peter Hagell,Andrew J. Lees,Tammaryn Lashley,Niall Quinn,Stig Rehncrona,Anders Björklund,Håkan Widner,Tamas Revesz,Olle Lindvall,Patrik Brundin +13 more
TL;DR: Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11–16 years) developed α-synuclein–positive Lewy bodies in grafted neurons, providing the first evidence, to the authors' knowledge, that the disease can propagate from host to graft cells.
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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
Christian Hansen,Elodie Angot,Ann-Louise Bergström,Jennifer A. Steiner,Laura Pieri,Gesine Paul,Tiago F. Outeiro,Ronald Melki,Pekka Kallunki,Karina Fog,Jia-Yi Li,Patrik Brundin +11 more
TL;DR: In vivo transfer of α-syn between host cells and grafted dopaminergic neurons in mice overexpressing human α- syn and results suggest that α- Syn propagation is a key element in the progression of Parkinson disease pathology.
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Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
Staffan Holmqvist,Oldriska Chutna,Luc Bousset,Patrick Aldrin-Kirk,Wen Li,Tomas Björklund,Zhan-You Wang,Laurent Roybon,Ronald Melki,Jia-Yi Li,Jia-Yi Li +10 more
TL;DR: The first experimental evidence that different α-synuclein forms can propagate from the gut to the brain is provided, and that microtubule-associated transport is involved in the translocation of aggregated α- synuclein in neurons is provided.
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Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation.
Anke Brederlau,Ana Sofia Correia,Sergey V. Anisimov,Muna Elmi,Gesine Paul,Laurent Roybon,Asuka Morizane,Filip Bergquist,Ilse Riebe,Ulf Nannmark,Manolo Carta,Erik Hanse,Jun Takahashi,Yoshiki Sasai,Keiko Funa,P. Brundin,Peter S. Eriksson,Jia-Yi Li +17 more
TL;DR: Investigation of the effect of in vitro predifferentiation on in vivo survival and differentiation of hESCs implanted into the 6‐OHDA (6‐hydroxydopamine)‐lesion rat model of PD indicates that prolonged in vitro differentiation ofhESCs is essential for preventing formation of teratomas.
Journal ArticleDOI
Research in motion: the enigma of Parkinson's disease pathology spread
TL;DR: The paper discusses the possible underlying mechanisms and their implications for how pathology spreads in Parkinson's disease and demonstrates that grafted healthy neurons can gradually develop the same pathology as host neurons in the diseased brains.